著者

KAZUHITO YOKOYAMA AKINORI NAKATA YUTO KANNARI FRANK NICKEL NICOLE DECI ANDREAS KRAUSE JAN DETTMERS

出版者

The Juntendo Medical Society

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

pp.JMJ21-0039-OA, (Released:2022-05-27)

参考文献数

22

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Objective The concept of self-endangering work behavior (SEWB) was recently proposed to describe problematic behaviors to cope with heavy workloads and self-management. Although SEWB may enable workers to achieve immediate goals, it risks health and long-term work capacity. In this study, we developed a Japanese version of the SEWB (J-SEWB) scale, which was originally in German, and verified its validity and reliability.Materials The original SEWB scale consisted of 21 items, constituting five subscales: “Intensification of working hours,” “Prolongation/extension of working hours,” “Refraining from recovery/leisure activities,” “Working despite illness,” and “Use of stimulating substances.” We translated the scale into Japanese, then checked the wording using back-translation.Methods The J-SEWB scale and questions for working conditions and sociodemographic variables was administered via an online survey with 600 participants registered with an internet survey company in Japan. Cronbach’s α coefficients were calculated for each subscale to assess internal consistency. Construct validity was examined using principal factor analysis with equamax rotation. An analysis of variance evaluated the relationships of J-SEWB scores with working conditions and sociodemographic variables.Results Cronbach’s α coefficients ranged from 0.846 to 0.964 for five subscales, and 0.957 for all 21 items (total J-SEWB score) in 600 participants. The factor analysis identified five factors, classifying 21 items into corresponding subscales. Total J-SEWB scores were significantly higher for flexible work as well as longer working hours.Conclusions The J-SEWB scale appears to be an effective tool for assessing SEWB in Japanese employees, with satisfactory reliability and construct validity.

著者

SHIYUE HE KAZUO KEMPE YUICHI TOMIKI MASAKO NISHIZUKA TSUTOMU SUZUKI TAKASHI DAMBARA TAKAO OKADA

出版者

The Juntendo Medical Society

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

vol.61, no.2, pp.142-148, 2015 (Released:2015-08-06)

参考文献数

10

被引用文献数

3 8

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Purpose: The present study was conducted to compare students’ entrance examination scores for a school and their grades following admission to discuss the methods for implementing screening tests and advice or guidance for students admitted to the school.Subjects and Methods: The subjects were students who took the general entrance examination for the Faculty of Medicine of Juntendo University and were admitted between 2004 and 2006. The entrance examination scores and academic performance were converted using a scale of one to 100, and Pearson’s product-moment correlation coefficient was calculated.Results: There were significant correlations between the English test scores for the entrance examination and academic performance in many subjects. On the other hand, there were non-significant negative correlations between the mathematics test scores for the entrance examination and academic performance in many other subjects.Conclusion: Students’ English test scores for the entrance examination are important since their academic performance following admission can be predicted from them. Students’ mathematics test scores for the entrance examination were negatively correlated with their academic performance in many subjects. Therefore, when students are provided with guidance for learning following admission, their mathematics scores should be taken into consideration.

著者

REI MOMOMURA

出版者

The Juntendo Medical Society

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

vol.68, no.1, pp.31-35, 2022 (Released:2022-02-28)

参考文献数

15

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Osteoporosis is an important issue related to life expectancy and healthy life expectancy in Japan, where the super-aging population is growing. Currently, in Japan, some kind of assistance is needed for an average of 10 years at the end of life. In many cases the reason assistance is needed is loss of mobility due to a fracture caused by a fall. When people suffer one fracture due to osteoporosis, they are also more likely to have another fracture, which is called a secondary fracture. Breaking the negative chain of fractures is very important in osteoporosis. In addition, if patients suffer a loss of mobility due to a compression fracture of the spine, this activity cannot be regained even if the fracture is healed. To prevent this from happening, it is also important to heal fractures rapidly, so that patients can quickly return to normal life, thus extending healthy life expectancy.

著者

TAKANORI WAKAYAMA

出版者

The Juntendo Medical Society

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

vol.64, no.Suppl.1, pp.135, 2018 (Released:2019-06-26)

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Introduction: Omega-3 polyunsaturated fatty acids (PUFA) such as eicosapentaenoic acid (EPA) are believed to prevent the progression of osteoarthritis (OA), since they act as an antioxidant and possess anti-inflammatory effect to suppress protein catabolism in cartilage and synovial cells. However, association between oxidative stress and fatty acid (FA)-related markers in synovial fluid of knee OA have not been fully understood. Therefore, the aim of this study is to investigate the relationships between oxidative stress and FA-related markers in the patients with knee OA.Methods: We examined the oxidative stress- and FA-related markers both in the serum and synovial fluid taken from the patients with knee OA (male/female: 4/6). The Kellgren-Lawrence classification of knee OA in these patients were II-IV. The average age was 60.7 years old. The levels of biological antioxidant potential (BAP) and reactive oxygen metabolites (d-ROMs) were measured using free radical analytical system (FRAS4, Wismer Co.Ltd., Tokyo Japan). Omega-6 PUFA (arachidonic acid: AA), omega-3 PUFA (EPA), and eicosanoid (Leukotriene C4: LTC4, Thromboxane B2: TXB2, hydroxyeicosatetraenoic acid: HETE) were investigated as FA-related markers using LC/MS/MS method. In statistics, Spearman’s rank correlation coefficient (r) and statistical significance (p) were calculated using GraphPad Prism version 6.0 (GraphPad Software). The values of p<0.05 were considered to be statistically significant.Results: The serum level of BAP/d-ROMs ratio (antioxidant capacity) was lower than that of synovial fluid; 5.8 (95%CI: 4.9-6.6) in serum and 18.9 (13.2-24.7) in synovial fluid (p<0.01, paired t-test), the ratio of serum/synovial fluid was 0.31, suggesting that antioxidant capacity within joint is higher than that in serum. The ratio of serum/synovial fluid of FA were as follows; EPA: 3.8 (1.5-6.1), DHA: 0.4 (0.2-0.6), AA: 0.7 (0.5-0.9). The serum/synovial fluid ratio of EPA/AA (indicator of the anti-inflammatory capacity) was 4.3 (1.3-7.3). These data indicates that the levels of FA in synovial fluid depend on the types of FA, and FA-related anti-inflammatory capacity is low in the synovial fluid of knee OA. There were significant negative correlation between the levels of BAP/d-ROMs and AA, LTC4, 15HETE, 12HETE (r=-0.72, -0.79, -0.85, -0.68, respectively, p<0.05) in synovial fluid, whereas no correlation in serum, suggesting that oxidative stress within knee joint are related to the activation of AA cascade.Discussion: We examined the relationships between oxidative stress and FA metabolism both in serum and synovial fluid of knee OA and found that oxidative stress in synovial fluid was involved in the AA cascade. Since omega-3 PUFA such as EPA and DHA poses anti-inflammatory effect, administration of these FA would be helpful to relief the inflammation of knee OA via suppression of oxidative stress within knee joint. Furthermore, our data suggest that the improvement of systematic methaboric conditions such as hyperlipidemia can loose their body weights in obesity individuals as well as surpress inflammation within the knee joint. Therefore, it’s important to evaluate general health conditions when we manage the patients with OA.

著者

TAKASHI ABE YOSHIMITSU KOHMURA KOYA SUZUKI YUKI SOMEYA JEREMY P. LOENNEKE SHUICHI MACHIDA HISASHI NAITO

出版者

The Juntendo Medical Society

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

pp.JMJ23-0017-P, (Released:2023-07-24)

参考文献数

21

被引用文献数

4

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Handgrip strength as a biomarker is being studied as a factor in predicting disease onset. However, the effect of improving handgrip strength through physical exercises, such as sports during the developmental period, on disease prevention has yet to be fully elucidated. The Juntendo Fitness Plus (J-Fit Plus) Study is a unique database of anthropometric and physical fitness measurements with over 50 years of accumulated data. It has the potential to explore the effects of sports on the association between handgrip strength and morbidity/mortality. We first outline previous studies on the impact of physical exercise interventions on handgrip strength, separated into adulthood and developmental period. We then introduced a unique effort to investigate the effects of sports using the J-Fit Plus Study database and describe the challenges of finally elucidating the impact of exercise on the association between handgrip strength and health status.

著者

TAKENORI INOMATA JAEMYOUNG SUNG ALAN YEE AKIRA MURAKAMI YUICHI OKUMURA KEN NAGINO KENTA FUJIO YASUTSUGU AKASAKI AKIE MIDORIKAWA-INOMATA ATSUKO EGUCHI KEIICHI FUJIMOTO TIANXIANG HUANG YUKI MOROOKA MARIA MIURA HURRAMHON SHOKIROVA KUNIHIKO HIROSAWA MIZU OHNO HIROYUKI KOBAYASHI

出版者

The Juntendo Medical Society

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

pp.JMJ22-0032-R, (Released:2023-01-26)

参考文献数

63

被引用文献数

1

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During the 5th Science, Technology, and Innovation Basic Plan, the Japanese government proposed a novel societal concept -Society 5.0- that promoted a healthcare system characterized by its capability to provide unintrusive, predictive, longitudinal care through the integration of cyber and physical space. The role of Society 5.0 in managing our quality of vision will become more important in the modern digitalized and aging society, both of which are known risk factors for developing dry eye. Dry eye is the most common ocular surface disease encountered in Japan with symptoms including increased dryness, eye discomfort, and decreased visual acuity. Owing to its complexity, implementation of P4 (predictive, preventive, personalized, participatory) medicine in managing dry eye requires a comprehensive understanding of its pathology, as well as a strategy to visualize and stratify its risk factors. Using DryEyeRhythm®, a mobile health (mHealth) smartphone software (app), we established a route to collect holistic medical big data on dry eye, such as the subjective symptoms and lifestyle data for each individual. The studies to date aided in determining the risk factors for severe dry eye, the association between major depressive disorder and dry eye exacerbation, eye drop treatment adherence, app-based stratification algorithms based on symptomology, blink detection biosensoring as a dry eye-related digital phenotype, and effectiveness of app-based dry eye diagnosis support compared to traditional methods. These results contribute to elucidating disease pathophysiology and promoting preventive and effective measures to counteract dry eye through mHealth.

著者

YUKA MUROFUSHI

出版者

The Juntendo Medical Society

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

vol.66, no.Suppl.1, pp.58-69, 2020 (Released:2020-09-30)

参考文献数

36

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Recently, the anti-doping movement has worked to improve the image of sports. Historically, doping inspection was implemented as a deterrent. A serious problem in recent years has been the violation of anti-doping regulations through intake of supplements mixed with prohibited substances. Unlike prescribed medications with clear ingredients, there are no international rules governing the manufacture of supplements or labelling of their ingredients. If the results of the doping control process are presumptive positive, a hearing will be arranged where athletes can present their case; however, insufficient labeling is not considered a good defense in itself. Code 2015, the current anti-doping rule, emphasizes the role and responsibilities of athletes and if a banned substance is present in the body it is a violation of this rule, whether intentionally or not. Recent studies have found that Japanese university athletes are generally lacking in anti-doping knowledge, as well as a lack of medical knowledge and little recognition of their responsibilities as athletes. Given these circumstances, anti-doping education has started to shift from a “deterrent approach” aimed at detecting fraud to a “preventive approach” aimed at inculcating the importance of ethics in sports. There are also guidelines to ensure that these lessons are learned as soon as possible. Code 2021, to be enacted in 2021, is the first time that International Standards for Education (ISE) will be formulated. Education to further raise awareness of anti-doping by developing ISE is also expected.

著者

MASAKAZU MATSUSHITA KEN YAMAJI NAOTO TAMURA

出版者

The Juntendo Medical Society

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

vol.66, no.1, pp.21-26, 2020 (Released:2020-02-29)

参考文献数

22

被引用文献数

2

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Rheumatoid arthritis (RA) is a chronic inflammatory disease that causes persistent inflammation, primarily in the synovial membrane of the joints. It may cause joint pain, swelling, and even deformation. Due to the strong involvement of abnormal immune function in its pathogenesis, RA is classified as a connective tissue disease. Most RA patients initially develop articular symptoms such as finger stiffness, pain, and swelling. They often visit medical institutions primarily complaining of these symptoms. However, it is known that manifestations of RA are found not only in the joints but also in a variety of organs in the entire body, including the lungs, skin, eyes, and blood vessels. These manifestations are called extra-articular manifestations, and they pose a problem as they significantly affect the patient’s activities of daily living (ADL), quality of life (QOL), and life expectancy. The pathology of RA has been elucidated in detail thanks to recent advances in molecular biology, and treatment strategies have undergone marked changes with the advent of biological drugs. Previously, the primary treatment goal was pain relief. Now, complete remission is becoming a reality with the prevention of bone destruction by completely inhibiting disease activity. However, extra-articular symptoms such as those involving the lungs pose major obstacles in drug selection for RA in many cases. When diagnosing and treating RA, it is important to not only evaluate articular manifestations but also accurately identify extra-articular manifestations and act appropriately.

著者

TAKENORI INOMATA JAEMYOUNG SUNG ALAN YEE AKIRA MURAKAMI YUICHI OKUMURA KEN NAGINO KENTA FUJIO YASUTSUGU AKASAKI AKIE MIDORIKAWA-INOMATA ATSUKO EGUCHI KEIICHI FUJIMOTO TIANXIANG HUANG YUKI MOROOKA MARIA MIURA HURRAMHON SHOKIROVA KUNIHIKO HIROSAWA MIZU OHNO HIROYUKI KOBAYASHI

出版者

The Juntendo Medical Society

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

vol.69, no.1, pp.2-13, 2023 (Released:2023-02-28)

参考文献数

63

被引用文献数

1

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During the 5th Science, Technology, and Innovation Basic Plan, the Japanese government proposed a novel societal concept -Society 5.0- that promoted a healthcare system characterized by its capability to provide unintrusive, predictive, longitudinal care through the integration of cyber and physical space. The role of Society 5.0 in managing our quality of vision will become more important in the modern digitalized and aging society, both of which are known risk factors for developing dry eye. Dry eye is the most common ocular surface disease encountered in Japan with symptoms including increased dryness, eye discomfort, and decreased visual acuity. Owing to its complexity, implementation of P4 (predictive, preventive, personalized, participatory) medicine in managing dry eye requires a comprehensive understanding of its pathology, as well as a strategy to visualize and stratify its risk factors. Using DryEyeRhythm®, a mobile health (mHealth) smartphone software (app), we established a route to collect holistic medical big data on dry eye, such as the subjective symptoms and lifestyle data for each individual. The studies to date aided in determining the risk factors for severe dry eye, the association between major depressive disorder and dry eye exacerbation, eye drop treatment adherence, app-based stratification algorithms based on symptomology, blink detection biosensoring as a dry eye-related digital phenotype, and effectiveness of app-based dry eye diagnosis support compared to traditional methods. These results contribute to elucidating disease pathophysiology and promoting preventive and effective measures to counteract dry eye through mHealth.

著者

YUKO NAKANISHI SHINOBU SAKURAI YUJIRO KAWATA YOSHIO SUZUKI MAYUMI TAKAYA SHIMPEI FUJITA KEISHOKU SAKURABA MASATAKA HIROSAWA TAKAO OKADA

出版者

The Juntendo Medical Society

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

vol.66, no.4, pp.337-345, 2020 (Released:2020-08-31)

参考文献数

25

被引用文献数

6 5

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Objective: This study examined the prevalence of and factors affecting normal weight obesity (NWO) among women aged under 40 years old. NWO was having a normal BMI but a high body-fat percentage (BFP).Materials and Methods: We recruited 399 participants aged 18-39 during a health checkup and surveyed them about lifestyle patterns, height, weight, body composition, and girth and visceral fat area. Participants were divided into three. Those with a BMI of <25 and a BFP of <30 were classified as non-obese, a BMI of <25 and a BFP of ≥30 as NWO, a BMI of ≥25 and a BFP of ≥30 as obese. The analysis was conducted on NWO (97) and non-obese (262) groups.Results: NWO prevalence ranged from 20% to 30% across the three age groups. NWO participants had lower values for segmental lean body mass, particularly in lower limb, and higher values for abdominal girth and visceral fat area. Among participants aged 30-39, those with NWO had higher values for triglycerides and LDL cholesterol and lower values for HDL cholesterol. Regarding lifestyle factors, among those aged 30-39, NWO was associated with past weight fluctuation, respectively. In the latter age group, a gain of more than 10 kg since the age of 20 was associated with a 13-fold increase in the odds for NWO.Conclusions: Results suggest that for women under 40 years, detecting NWO early and guidance on effective lifestyle and exercise are necessary.

著者

YUKA HONDA MITSUYOSHI SUZUKI YUICHI SATO KEIJI KURODA HIROMICHI SHOJI TOSHIAKI SHIMIZU

出版者

The Juntendo Medical Society

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

vol.62, no.2, pp.153-159, 2016 (Released:2016-07-02)

参考文献数

30

被引用文献数

1

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Objective: The aim of this study was to investigate the associations of anti-Müllerian hormone (AMH) levels with physique and 25-hydroxyvitamin D (25OH-D) levels in healthy women of reproductive age based on measurements of nutritional status and physical constitution.Materials and Methods: Subjects comprised 108 non-obese women (age range, 21-39 years) who underwent examination of their physique, blood biochemistry and nutritional state. For data analysis, subjects were first divided by age. AMH levels were grouped by serum 25OH-D concentration using Holick’s classification: deficiency, <30 ng/ml; and sufficiency, ≥30 ng/ml.Results: Mean levels were 25.2±8.4 ng/ml for serum 25OH-D and 4.9±2.4 ng/ml for AMH. Overall, 76 women (70.4%) were diagnosed with 25OH-D deficiency. Serum AMH levels were significantly lower in subjects with 25OH-D deficiency (4.5±2.5 ng/ml) than in those with 25OH-D sufficiency (5.7±1.9 ng/ml; p<0.01). Significant differences were seen in the frequency of subjects with 25OH-D deficiency and sufficiency between low AMH (<2.2 ng/ml) status and normal AMH (≥2.2 ng/ml)(16/17 [94.1%] vs. 1/17 [5.9%] for low AMH status; 60/91 [65.9%] vs.31/91 [34.1%] for normal AMH status, respectively; p<0.05). Independent predictors of serum AMH levels≥2.2 ng/ml were serum 25OH-D level (p<0.05) and age (p<0.05) according to binary logistic regression analysis.Conclusions: Decreased serum AMH level is associated with vitamin D deficiency, but is unrelated to physique state in this population.

著者

TAKENORI INOMATA JAEMYOUNG SUNG MASAHIRO NAKAMURA MASAO IWAGAMI YUICHI OKUMURA KENTA FUJIO YASUTSUGU AKASAKI KEIICHI FUJIMOTO AI YANAGAWA AKIE MIDORIKAWA-INOMATA KEN NAGINO ATSUKO EGUCHI HURRRAMHON SHOKIROVA JUN ZHU MARIA MIURA MIZU KUWAHARA KUNIHIKO HIROSAWA TIANXING HUANG YUKI MOROOKA AKIRA MURAKAMI

出版者

The Juntendo Medical Society

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

vol.67, no.6, pp.519-529, 2021 (Released:2021-12-31)

参考文献数

67

被引用文献数

9

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Society 5.0, a visionary human-centered societal model, fuels economic development and resolves long-standing social problems. The model establishes a technological foundation and social contract to integrate cyberspace into the physical (real) space fully. The medical infrastructure outlined by the model envisions a healthcare paradigm that revolves around preventative, lifelong patient- and population- centered care that functions seamlessly within one's daily life. In satisfying this goal, cross-hierarchical integrative data-driven biological research has received attention due to medical big data and artificial intelligence (AI) technologies, capable of highly accurate and rapid data analysis. However, the collection of big data has been a bottleneck, and the capability of AI analysis is not being utilized to its full potential. In solving this obstacle, we explore mobile health (mHealth) and multi-omics as two rich sources of medical big data. Additionally, we discuss the implications of cross-hierarchical integrative analysis that encompasses all levels of cellular function, from intracellular molecular dynamics to end-phenotypes. This is to understand ocular disease pathology and implement the pillars of P4 (predictive, personalized, preventative, participatory) medicine toward human-centered healthcare. Here, we discuss notable studies in utilizing mHealth to stratify subjective symptoms, presentations of dry eye disease, and employing multi-omics machine learning targeted at elucidating immunologic mechanisms of corneal allograft rejection and ocular inflammation. We also discuss the role of cross-hierarchical integrative data-driven research in promoting future-oriented healthcare envisioned by the Society 5.0 plan.

著者

XUEKUN YANG JING BAI HISAMASA IMAI

出版者

The Juntendo Medical Society

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

vol.62, no.3, pp.240-247, 2016 (Released:2016-11-02)

参考文献数

17

被引用文献数

1 2

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Objective: We aimed to reveal the declining status of autopsy rate in Japanese university hospitals during the last 34-year period, to draw attention to the importance of autopsy.Methods: Autopsy related data from 1979 to 2012 in all Japanese university hospitals were collected and analyzed on annual basis under categories of Juntendo University Hospital, Japanese university hospitals, public university hospitals and private university hospitals separately. Trends of changes in autopsy rate from 1979 to 2012 were plotted and compared between the groups.Results: The autopsy rate in Juntendo University Hospital was maintained at the levels of 50-60% until 1986, then started to decline steadily and reached to 9.7% in 2012. Regression coefficient of the autopsy rate during the 34-year period was -0.0173. The mean autopsy rate of all university hospitals in Japan was maintained at 45% until 1983, then started declining steadily and reached to 6.8% in 2012. Of these hospitals, the mean autopsy rate in public hospitals was still kept at 45% in 1985 but continued declining to 9.3% in 2012, while in private hospitals it reached to 45% in 1983 and kept declining to only 5.6% in 2012.Conclusion: The steady decline of the autopsy rate in university hospitals in Japan began early 1980’; this trend still continues, and the autopsy rate declined to 6.8% in 2012. We should work to prevent the decline of autopsy rate furthermore in Japanese university hospitals.

著者

TAKAHIRO WATANABE

出版者

The Juntendo Medical Society

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

vol.66, no.Suppl.1, pp.83-87, 2020 (Released:2020-09-30)

参考文献数

4

被引用文献数

2

著者

MICHIKO MOCHIZUKI SUDO AKITO AZUMANE MOCHIZUKI EIJI KIRINO KENJI ITOH

出版者

The Juntendo Medical Society

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

pp.JMJ19-OA21, (Released:2020-02-18)

参考文献数

36

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Objective: Research has demonstrated the positive effects of physical activities on social cognition. The purpose of the present study was to find out whether coordination exercises have a beneficial effect on enhancing social functioning. We investigated the activation of the brain areas associated with doing one-person coordination exercises, as compared to doing two-person coordination exercises. We were interested in testing the hypothesis that two-person coordination exercises activate those brain areas underlying communication abilities, empathy in “theory of mind” (ToM), and working memory in social cognition. Materials: Thirty-four Japanese college students served as subjects. Methods: In the MRI system, the subjects carried out block-designed cognitive tasks containing affective visual stimuli (pleasant, unpleasant, and neutral stimuli). Then they got out of the MRI system and performed both one-person coordination and two-person coordination exercises. Just after the exercises, they were retested using the same types of the affective stimuli in the MRI system. We examined social abilities in terms of empathizing and memory span. Results: The present study provided evidence that coordination exercises activate language, working memory, and theory of mind functions. One of the fMRI results to be noted is that the right, but not the left, anterior cingulate correlated with the working memory function. Conclusions: We provided evidence for the effect of performing coordination exercises on the activation of the left frontal gyrus related to social functioning. We could also provide support for the hypothesis that two-person coordination exercises activate both the working memory function and the ToM function.

著者

MINORU KUNII SUSUMU S. SAWADA NAOFUMI YAMAMOTO YUKO GANDO HISASHI NAITO

出版者

The Juntendo Medical Society

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

pp.JMJ19-OA04, (Released:2019-12-13)

参考文献数

20

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Objective: The purpose of this study was to evaluate the relationship of freestyle swimming performance between adolescence and adult Japanese top-class swimmers.Methods: The 234 males and 134 females ranked in the top 100 records of 50, 100, 200 and 400 m freestyle short-course performances of over 22 years old during 2016 to 2018 (latest TIME), and their season best performances during 2006 to 2017 were analyzed. All data were collected from the public database “Swimrecord.com” by Japan Swimming Federation. Performance maturity status was determined by the ratio of each age record to the latest TIME and the relationship between the latest TIME and each age record was evaluated. Also, the subjects were divided into the upper or lower group with reference to the latest TIME and the developmental changes of performance were compared between the groups.Results: The performance maturity status was higher in females than males at each age. The correlation between the latest TIME and each age record became gradually stronger from males aged 17 years and females aged 14 years, but there was no clear correlation in the previous records. There was no difference in developmental changes in performance between the upper and lower groups in both males and females.Conclusions: The longitudinal analysis of the swimming performance in the growth period reveals that the Japanese top-class swimmers show high performance before 12 years old and that the time to approximate peak performance appeared earlier in females than in males and the relationship is different depending on swimming distance.

著者

TOMOHIRO NAKAMURA RYO KAKIGI NORIKO ICHINOSEKI-SEKINE TAKAMASA TSUZUKI HIROYUKI KOBAYASHI KAZUHIKO SAKUMA HISASHI NAITO

出版者

The Juntendo Medical Society

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

pp.JMJ19-OA08, (Released:2019-09-25)

参考文献数

21

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Objective: Alpha-actinin (ACTN) 3 R577X polymorphisms have three genotypes: RR, RX and XX. Only RR and RX genotypes express ACTN3 protein in type II fibers. The purpose of this study was to clarify whether there are differences in ACTN3 protein expression levels and myosin heavy chain (MyHC) composition between RR and RX genotypes in Japanese college-level male sprinters.Materials and Methods: Forty-three Japanese college-level male sprinters participated in this study. Subjects were genotyped for ACTN3 R577X using a real-time polymerase chain reaction assay. Furthermore, muscle biopsies from the vastus lateralis muscle were obtained from a subset of subjects who had R allele and gave their consent (4 RR and 9 RX). ACTN3 protein expression levels were assessed by western blotting. MyHC composition was determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis.Results: There was no difference in 100-m sprint performance among RR, RX and XX genotypes in all 43 subjects. In 13 biopsy-sampled subjects, there was also no difference in 100-m sprint performance between RR and RX and ACTN3 protein expression levels tended to be higher in RR genotype than in RX genotype. Although there were no differences in the proportion of type I and II MyHC isoforms between both genotypes, RR genotype had a significantly higher proportion of type IIx MyHC isoform and a significantly lower proportion of type IIa MyHC isoform than RX genotype.Conclusions: ACTN3 protein expression levels and the proportion of type IIx MyHC isoform are higher in RR genotype compared with RX genotype in Japanese college-level male sprinters.

著者

OKIO HINO

出版者

The Juntendo Medical Society

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

vol.60, no.6, pp.588, 2014 (Released:2015-06-03)