著者

Yosuke KOSAKA Yoshihisa MATSUDA

出版者

Meteorological Society of Japan

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

vol.83, no.4, pp.481-498, 2005 (Released:2005-10-07)

参考文献数

12

被引用文献数

2 3

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In order to resolve the contradiction between the theories proposed by Rodwell and Hoskins (1996) and Chen et al. (2001), a linear response of global/hemispherical atmosphere to a subtropical heat source is studied, using two different numerical models. The first model treats the response as a linear combination of wave components (Hough functions), which are eigenmodes of the homogeneous equations. The second model is based on quasi-geostrophic approximation.First, the response to zonally uniform heat source is investigated. In the case of the heat source centered at the equator, geopotential and zonal wind perturbation fields are expressed by Rossby and Kelvin modes, while vertical and meridional flows are represented by gravity modes. On the other hand, the case of the heat source centered off the equator reveals that the cell reaching winter hemisphere is dominant due to mixed Rossby-gravity mode.Second, the response to zonally localized heat source centered at 25°N is investigated. The validity of quasi-geostrophic approximation in the subtropics is verified. It is found that the geopotential and horizontal wind perturbation fields can be expressed only by Rossby modes, while the contribution of gravity modes is stronger for the vertical flow. On the basis of these results we calculate the response in the observed basic wind, but the wavetrain shown in Chen et al. (2001) cannot be reproduced. On the other hand, the descent west or northwest of the heat source, which is examined in Rodwell Hoskins (1996), appears in the resting basic field as well as in the basic zonal flow. The mechanism producing this descent is discussed in detail.

著者

松田 佳久 Yoshihisa Matsuda

出版者

創価大学法学会

雑誌

創価法学 (ISSN:03883019)

巻号頁・発行日

vol.43, no.3, pp.109-124, 2014-03

著者

Makoto OTSUKA Hitoshi HASEGAWA Yoshihisa MATSUDA

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.45, no.5, pp.894-898, 1997-05-15 (Released:2008-03-31)

参考文献数

19

被引用文献数

35 50

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The effects of a solvent system on the pharmaceutical properties of carbamazepine (CBZ) granules containing a polymorphic form of bulk powder were investigated by X-ray diffraction analysis, thermal analysis, mercury porosimetry and Brunauer-Emmett-Teller (BET) surface area measurement. A powder mixture consisting of 20% CBZ form I, as a bulk powder, 56% crystalline α-lactose monohydrate and 24% corn starch was used as a pharmaceutical powder, with the three kinds of binder solutions (distilled water, 50% aqueous ethanol and ethanol) containing 5% hydroxypropylcellulose (HPC). After kneading with a binder solution, the granules were obtained using an extruding granulator. The X-ray diffraction and differential scanning calorimetry (DSC) results of the granules indicated that form I with 50% ethanol solution transformed into a dihydrate form during extruding granulation, but this did not occur with the distilled water or ethanol solutions. The order of hardness and specific surface area (Sw) of the granules was distilled water>50% ethanol>ethanol and 50% ethanol>ethanol>distilled water. The stress-thickness profiles of the tabletting compression processes of CBZ granules obtained using various binder solution systems were measured, and the initial compression process due to particle rearrangement was affected by the characteristics in the granules. The total pore volume of tablets obtained from 50% ethanol was the lowest, and their order was ethanol>distilled water>50% ethanol. Their order of tablet hardness reflected the total pore volume of the tablet, and was 50% ethanol>distilled water>ethanol. All pharmaceutical properties of the granules and/or tablets containing CBZ were affected by the characteristics of the solvent systems in binder solution.

著者

Takashi Kojima Fumie Kato Reiko Teraoka Yoshihisa Matsuda Shuji Kitagawa Mitsutomo Tsuhako

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.55, no.3, pp.407-411, 2007 (Released:2007-03-01)

参考文献数

25

被引用文献数

9 11

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Two novel pseudopolymorphs, methanolate and ethanolate of tamoxifen [(Z)-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine]citrate, were prepared in addition to forms A and B reported previously. Their crystalline forms were identified and characterized by powder and single crystal X-ray diffractometry, differential scanning calorimetry, thermogravimetric analysis, hot-stage microscopy, scanning electron microscopy and diffuse reflectance infrared Fourier-transform spectroscopy, and their physicochemical stability was also evaluated. The results of single crystal X-ray analysis and thermogravimetric analysis of methanolate and ethanolate suggested that the stoichiometry of tamoxifen citrate : methanol and tamoxifen citrate : ethanol could be composed of a 1 : 1 molecular ratio for both solvates. The results of physicochemical stability evaluations at 75 and 97% RH at 40 and 60 °C indicated that the metastable form A was quite stable for at least 2 months even under severe storage conditions, whereas methanolate immediately transformed to a crystalline mixture of forms A and B, and subsequently changed to the stable form B.

著者

松田 佳久 Yoshihisa Matsuda

出版者

創価大学法学会

雑誌

創価法学 = The Soka law review (ISSN:03883019)

巻号頁・発行日

vol.45, no.2, pp.199-215, 2015-12