著者

Masami INADA Shigeya WATANABE Yoshio WAKATSUKI Hiroyuki KUDO Motonobu MURAKAMI Takeo MIYAKE

出版者

SOCIETY FOR FREE RADICAL RESEARCH JAPAN

雑誌

Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)

巻号頁・発行日

vol.3, no.3, pp.201-207, 1987 (Released:2010-02-25)

参考文献数

5

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Effect of administration of active vitamin D3 on the histological changes of intestinal mucosa was studied in normal rats treated with 0.25 to 0.5μg of 1α(OH)D3 or 1α, 25(OH)2D3. Mucosal thickness, cell count and volume, mucosal mass, and nuclear size were morpho-metrically measured in the villi and crypts. In the villi, both 1α(OH)D3 and 1α, 25(OH)2D3 significantly increased the cell counts, moderately increased the thickness, and slightly increased the cell volume, compared with the control group. Neither agent had any effect on the crypts. Nuclear size in villi was increased only in the 1α, 25(OH)2D3 group.