著者

Yukihiro Ikeda

出版者

The Japanease Society for the History of Economic Thought

雑誌

経済学史研究 (ISSN:18803164)

巻号頁・発行日

vol.50, no.1, pp.79-95, 2008-07-31 (Released:2010-08-05)

参考文献数

80

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This article surveys the major secondary literature on the German Historical school produced for the most part from the 1990s onward. Following a brief introduction, and using the customary terms Older, Younger, and Youngest to identify periods of development in the school, I note with critical comment works on the Older Historical school. Then in the following section we turn to work done on the Younger and Youngest members of the School. In the last section, centering on the questions of what has been accomplished and what is necessary to promote further studies, some general suggestions are given regarding future research.

著者

Yukihiro Ikeda Junko Ban Tomoyasu Ishikawa Shohei Hashiguchi Shinichi Urayama Hidetoshi Horibe

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.56, no.10, pp.1406-1411, 2008-10-01 (Released:2008-10-01)

参考文献数

29

被引用文献数

20 32

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TAK-599 (known as ceftaroline fosamil) is a novel N-phosphono type prodrug of a cephalosporin compound, T-91825, that exhibits strong activity against methicillin resistant Staphylococcus aureus (MRSA). The stability and stabilization of TAK-599 were investigated by kinetic analysis focused on crystallinity and moisture content. Initially it was planned to develop TAK-599 as an injectable formulation using the amorphous solid powder prepared by lyophilization. However, amorphous of TAK-599 free form was found to be chemically unstable even when stored at 8 °C, and thus development was focused on the crystalline material. After exhaustive screening of crystallization condition, the monoacetic acid solvate was found to yield TAK-599 in a crystalline form. Physicochemical properties were studied to identify the key factors affecting the stabilization of TAK-599 in order to improve long-term stability, and the results indicated that the crystallinity of TAK-599 correlated with stability. Furthermore, moisture content was also identified in our studies as an important factor in stabilizing TAK-599. TAK-599 containing about 3% moisture was found to be the most stable form. It was concluded that both sufficient crystallinity and strict moisture control of TAK-599 were essential to maintain long-term stability at 25 °C.