2 0 0 0 OA Adverse Effects of Kampo Medicines
- 著者
- Yutaka Shimada
- 出版者
- The Japanese Society of Internal Medicine
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- vol.61, no.1, pp.29-35, 2022-01-01 (Released:2022-01-01)
- 参考文献数
- 21
- 被引用文献数
- 2 16
This review summarizes the adverse effects of Kampo medicines. These adverse effects in terms of immunoallergic reactions include interstitial pneumonia, liver injury, allergic cystitis, and drug eruption. Many cases of interstitial pneumonia, liver injury, and allergic cystitis associated with Kampo formulas have been reported to be caused by formulas containing Scutellariae Radix (Scutellaria root, ogon). The known adverse effects linked to overdose of Kampo formulas include pseudoaldosteronism [caused by Glycyrrhizae Radix (licorice, kanzo)], sympathomimetic symptoms [caused by Ephedrae Herba (ephedra, mao)], aconite poisoning [caused by Aconiti Tuber (processed aconite root, bushi and uzu)], and diarrhea [caused by Rhei Rhizoma (rhubarb, daio)]. In recent years, mesenteric phlebosclerosis caused by the long-term administration of Gardeniae Fructus (gardenia fruit, sanshishi) has also been reported. It is necessary to consider these potential adverse effects when prescribing Kampo medicines in clinical practice.
2 0 0 0 OA Similarities of inter-point distance distributions on original and reconstructed attractors
- 著者
- Kazuya Sawada Yutaka Shimada Tohru Ikeguchi
- 出版者
- The Institute of Electronics, Information and Communication Engineers
- 雑誌
- Nonlinear Theory and Its Applications, IEICE (ISSN:21854106)
- 巻号頁・発行日
- vol.13, no.2, pp.385-390, 2022 (Released:2022-04-01)
- 参考文献数
- 22
State space reconstruction using time-delay coordinate systems is the most effective and significant technique for analyzing complex time series generated by nonlinear dynamical systems. In this study, we investigated the relationships between reconstruction parameters and the similarity of the structural properties of original and reconstructed attractors. In particular, we investigated the similarities between inter-point distance distributions on original and reconstructed attractors, while varying the reconstruction parameters for reconstructing a dynamical system using a time-delay coordinate system. The results show that the product of the reconstruction dimension and the time-delay should be constant to obtain high similarity.
- 著者
- Eiichi TAHARA Tadamichi MITSUMA Yutaka SHIMADA Takashi ITOH Katsutoshi TERASAWA
- 出版者
- The Japan Society for Oriental Medicine
- 雑誌
- Kampo Medicine (ISSN:02874857)
- 巻号頁・発行日
- vol.48, no.3, pp.341-348, 1997-11-20 (Released:2010-03-12)
- 参考文献数
- 17
- 被引用文献数
- 1 2
今回我々はバセドウ病による甲状腺機能亢進症に対して抗甲状腺剤を用いることなく, 漢方方剤のみによる治療を行い, 寛解に至った症例を報告した。症例1は47歳, 女性。約2年前より動悸, 体重減少, イライラ感, 耳鳴, めまい感など多愁訴。TSH低値, fT3・fT4・TBII高値, 123I 24時間摂取率高値からバセドウ病と診断。動悸などを目標に炙甘草湯を処方。その後証に応じて柴胡加龍骨牡蛎湯などを併用した。1年10ヶ月後には, TSH, fT3, fT4, TBIIとも正常化し, 以後現在まで正常域。症例2は40歳, 女性。3年前より動悸出現。近医で甲状腺機能亢進症を指摘され, 約2ヶ月間チアマゾールを内服。初診時TSH低値, fT3・fT4正常, TBII高値。動悸などを目標に炙甘草湯を処方。約3週後にチアマゾールを自己中止。証に応じて柴胡加龍骨牡蛎湯などを併用した。fT3, fT4は徐々に増加したが動悸は消失。10ヶ月後からfT3・fT4は徐々に低下傾向にある。甲状腺機能亢進症に対して抗甲状腺剤を用いることなく, 漢方治療のみで寛解に至らしめ得る病態のあることが示唆された。
- 著者
- Kihei Magishi Tomoko Matsumoto Yutaka Shimada Tohru Ikeguchi
- 出版者
- The Institute of Electronics, Information and Communication Engineers
- 雑誌
- Nonlinear Theory and Its Applications, IEICE (ISSN:21854106)
- 巻号頁・発行日
- vol.13, no.2, pp.343-348, 2022 (Released:2022-04-01)
- 参考文献数
- 22
Word co-occurrence networks (WCNs) are a major tool used to analyze languages quantitatively. In a WCN, the vertices are words (morphemes), and the edges connect n consecutive words in a sentence on the basis of the n-gram. Most studies use WCNs transformed at n=2. In this study, we investigated the changes in the structural features of WCNs when n increases using four types of documents for eight languages. We found that WCNs with n≧ 3 reflect features of the languages that do not appear when n = 2 and that some structural features evaluated by network measures depend on the text data.
- 著者
- Yutaka Shimada Makoto Fujimoto Tatsuya Nogami Hidetoshi Watari Hideyuki Kitahara Hiroki Misawa Yoshiyuki Kimbara Kei-ichiro Kita
- 出版者
- The Japanese Society of Internal Medicine
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- vol.57, no.12, pp.1733-1740, 2018-06-15 (Released:2018-06-15)
- 参考文献数
- 26
- 被引用文献数
- 11
A 67-year-old woman experiencing coughing visited a clinic and was prescribed drugs, including shosaikoto extract, for 4 days. She subsequently suffered from liver injury, but her condition improved after the discontinuation of all medications. Approximately 1 year later, she experienced fatigue, consulted another clinic, and received saikokeishikankyoto extract for 21 days. She subsequently suffered liver injury again. Both shosaikoto and saikokeishikankyoto contain Scutellariae Radix. This case is thought to be one of recurrent drug-induced liver injury caused by the incidental readministration of a Kampo formula containing Scutellariae Radix. An awareness of adverse drug events caused by Kampo formulas, especially those containing Scutellariae Radix, is essential.