著者

Kohei Tanaka Sho Katayama Kazuki Okura Masatsugu Okamura Keishi Nawata Nobuto Nakanishi Ayato Shinohara

出版者

The Japanese Society of Strategies for Cancer Research and Therapy

雑誌

Annals of Cancer Research and Therapy (ISSN:13446835)

巻号頁・発行日

vol.30, no.2, pp.93-99, 2022-07-21 (Released:2022-08-23)

参考文献数

53

被引用文献数

5

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The skeletal muscle has a significant role on physical functions, and the assessment of the skeletal muscle is important in critically ill patients. Computed tomography (CT), ultrasound examination, bioelectrical impedance analysis (BIA) device, and biomarkers can all be used to assess skeletal muscle mass. CT is useful for accurately measuring skeletal muscle mass, and the measurement is conducted at the third lumbar vertebra level as the gold standard. However, the assessment using CT is done retrospectively because CT involves radiation exposure and requires patients to be transported to the examination room. On the other hand, ultrasound and BIA are noninvasive and can be used at the bedside to assess longitudinal skeletal muscle mass. However, accurate assessment requires knowledge and skills. Assessments using BIA should be carefully interpreted because critically ill patients are under dynamic fluid change and edema. Furthermore, various biomarkers for the assessment of skeletal muscle mass have been recently reported. Appropriate skeletal muscle assessment will contribute to the nutrition and rehabilitation intervention of critically ill patients so that they can return to society.

著者

Mohammad Al Sorkhy Zina Fahl Jenna Ritchie

出版者

The Japanese Society of Strategies for Cancer Research and Therapy

雑誌

Annals of Cancer Research and Therapy (ISSN:13446835)

巻号頁・発行日

vol.26, no.1, pp.19-25, 2018-01-16 (Released:2018-03-27)

参考文献数

46

被引用文献数

9 9

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Breast cancer (BC) is a commonly diagnosed cancer amongst women and the second leading cause of cancer deaths in the world. BC has created huge challenges to healthcare providers regarding the identification of main risk factors and how they contribute to the development of the disease. Several studies suggest that biological risk factors such as duration of breast feeding, age at menarche, menopausal status and the use of contraceptive pills have contributed to the increase of BC diagnoses. Moreover, psychological factors such as depression, stress and negative lifestyles are gaining more attention as a major contributor to this type of cancer. The role of psychological stress regarding BC has been widely demonstrated in the literature across several fields including but not exclusive to epidemiology, physiology, and molecular biology which all show a clear relationship between intracellular stress signaling and protumorigenic pathways within breast cells. Cortisol is primary stress hormone of the human body and a growing body of research both clinically and molecularly are revealing a positive correlation of high cortisol levels and the progression of BC. This review attempts to establish and highlight how cortisol levels impact breast cancer development and progression.

著者

Barrios Arroyave A. Freddy Rodríguez Velásquez O. Javier Prieto Bohórquez E. Signed Grisales E. Carlos Correa Herrera C. Sandra Jattin Balcázar J. Jairo Soracipa Muñoz Ribka Ruiz Morales J. Jhon

出版者

The Japanese Society of Strategies for Cancer Research and Therapy

雑誌

Annals of Cancer Research and Therapy (ISSN:13446835)

巻号頁・発行日

vol.31, no.1, pp.7-12, 2023-02-14 (Released:2023-02-14)

参考文献数

26

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Introduction: fractal geometry has been implemented to study natures’ irregular objects with diverse applications in medicine, from characterizations of human structures such as the division of bronchial or arterial trees to the diagnosis of abnormal cells, as it has been evidenced in the study of neoplasms. In this investigation, a characterization of the degree of irregularity of histologic samples of normal and thyroid gland neoplasms was developed in the context of fractal and Euclidean geometry.Methods: photographs of normal and neoplastic thyroid histologic samples obtained as surgical pieces were processed by a software that allows to delimit the borders of cellular structures. Then, grids of 5 and 10 pixels were superimposed over the images in order to measure their surfaces and occupation spaces through the Box-Counting method.Results: For nucleus measures values between 14 to 34 in the 5 pixels grid and values between 7 to 16 in the 10 pixels grid suggest normality.Conclusions: The surface of the nucleus and the cytoplasm measured by grids of 5 and 10 pixels, allow to carry out a more objective characterizations of both normal and abnormal thyroid cells.

著者

Mazen Almehmadi Khalid Alzahrani Magdi M. Salih Abdulaziz Alsharif Naif Alsiwiehri Alaa Shafie Abdulraheem A. Almalki Ayman Alhazmi Haytham Dahlawi Mohammed S. Alharthi Mustafa Halawi Abdulrhman M. Almehmadi Hatem H. Allam

出版者

The Japanese Society of Strategies for Cancer Research and Therapy

雑誌

Annals of Cancer Research and Therapy (ISSN:13446835)

巻号頁・発行日

vol.28, no.2, pp.54-59, 2020-07-09 (Released:2020-07-09)

参考文献数

24

被引用文献数

2 2

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Background: Vitamin D roles in human health and wellbeing have been extensively studied in the recent years. It has essential roles in homeostasis and maintaining many physiological functions. These roles are vital in immune system, respiratory system, cardiovascular system, and reproductive system. Deficiency in this vitamin has been correlated with many diseases in the body, and it has been correlated with developing cancer.Objective: This study aimed to investigate levels of total vitamin D (25-hydroxycholecalciferol) in cancer patients.Design: Retrospective.Settings: Taif city- king Faisal Hospital (KFH).Patients and methods: Serum levels of 25-hydroxycholecalciferol were classified into normal, insufficient, and deficiency group, patients were grouped according to these classes.156 patients were included in this study, 128 females and 28 males, 100 healthy participants were included. Cancer patients were as follows, gastrointestinal tract cancer patients were 27, breast cancer patients were 73, female genital tract patients were 43, head and neck cancer patients were 6 and respiratory tract patients were 7.Sample size: 256 participants were 100 healthy controls and 156 cancer patients.Results: Deficiency was detected in most of the patients from both genders, and in both pre- and post-menopausal female patients.Conclusion: These findings support the belief that deficiency in vitamin D is a risk factor leading to development of cancer.

著者

Michitaka Honda Muhammad Wannous Kazumichi Yamamoto Akiko Yoshida

出版者

The Japanese Society of Strategies for Cancer Research and Therapy

雑誌

Annals of Cancer Research and Therapy (ISSN:13446835)

巻号頁・発行日

vol.30, no.1, pp.33-37, 2022-01-31 (Released:2022-04-19)

参考文献数

23

被引用文献数

2

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Background: We developed a new smartphone application to record images of daily meals and physical symptoms for postoperative gastrointestinal patients.Methods: Patients took pictures of their daily meals and uploaded them on the researcher’s server. They also entered the appetite, physical condition, and digestive symptoms. Two dietitians quantitatively assessed the images of diets and performed nutritional guidance for patients The primary endpoint was the percentage of evaluable meals during the study period (10 days).Results: Ten patients participated in the study as planned. The median age was 64 (32–72) years old, and there were six males and four females. Six patients underwent distal gastrectomy, three underwent total gastrectomy and one underwent esophagectomy. The mean postoperative time was 4.6 months. The percentage of evaluable dietary images was 94.6%.Conclusion: We confirmed the feasibility of the delivering nutritional guidance using a smartphone application for patients who have undergone gastrointestinal cancer surgery.

著者

Ainur Baizhumanova Junichi Sakamoto

出版者

The Japanese Society of Strategies for Cancer Research and Therapy

雑誌

Annals of Cancer Research and Therapy (ISSN:13446835)

巻号頁・発行日

vol.18, no.2, pp.65-68, 2010-11-26 (Released:2010-11-26)

参考文献数

9

被引用文献数

1

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Cancer is the third leading cause of premature death in Kazakhstan. Every year more than thirty thousand Kazakhstani people are diagnosed with cancer. The present article was undertaken to provide base for the cancer control programs in Kazakhstan. The most common types of cancer are lung, skin, breast and stomach. These four cancers combined account for over 44% of new cases of cancer. Lung cancer is the most common cancer in men accounting for nearly a quarter of cancer cases in men. Breast cancer is by far the most common cancer in women accounting for 20%. Cancer remains mainly a disease of older Kazakhstanis. The largest proportion of cancer deaths for both men and women were from lung cancer mainly caused by smoking. Deaths from cancers of the lung, stomach, breast and esophagus together accounted for almost a half (46%) of all cancer deaths. With an estimated 186.7 new cases and 166.7 deaths in 2006, cancer remains an important public health problem in Kazakhstan. The incidence of lung cancer, and several other forms of cancer, could be reduced by improved tobacco control and healthy lifestyle.

著者

Ammar Ebrahimi Pejman Abbasi Magali Cucchiarini

出版者

The Japanese Society of Strategies for Cancer Research and Therapy

雑誌

Annals of Cancer Research and Therapy (ISSN:13446835)

巻号頁・発行日

vol.28, no.1, pp.3-8, 2020-01-21 (Released:2020-01-21)

参考文献数

54

被引用文献数

3

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Tumors comprise two types of non-cancerous cells, first recruited cells such as stem cells and macrophages, and second, tissue-steady cells that are part of the tissue including adipose cells, fibroblasts, and steady macrophage-derived cells, all having a significant impact on tumor progression. This review addresses some effects of stem cells on cancer advancement as the predominant outcome of stem cell therapy on cancer cell lines revealed controversial results. In addition, this review will address some reasons of distinct cancer responses and hypotheses the notion of unfolded protein response as a key switch in cancer development.

著者

Hisanori Shoji Masahiko Motegi Kiyotaka Osawa Noriyuki Okonogi Atsushi Okazaki Yoshitaka Andou Takayuki Asao Hiroyuki Kuwano Takeo Takahashi Kyoji Ogoshi

出版者

The Japanese Society of Strategies for Cancer Research and Therapy

雑誌

Annals of Cancer Research and Therapy (ISSN:13446835)

巻号頁・発行日

vol.22, no.1, pp.28-35, 2014-06-27 (Released:2014-12-19)

参考文献数

30

被引用文献数

1 7

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Background: Hyperthermia has not been approved as a standard treatment method in oncology. One of the major problems is that there is no reference point for this therapy. Another problem is that radiofrequency hyperthermia has a fatal flaw, the hot spot phenomenon, which does not allow continuation of treatment without lowering the output. Patients and Methods: Hyperthermia treatment was administered either alone or concomitantly with chemotherapy and/or radiotherapy to 76 consecutive patients with malignancies, using Thermotron RF-8, between December 2011 and April 2014. Radiofrequency hyperthermia was administered 5 times for 5 weeks with 50 min irradiation in all patients. Results: Complete response (CR) was seen in 35.2% of primary cases, but in 4.5% of recurrent cases, and this rate was higher in patients with three days after first chemoradiation. There was significant correlation among the initial irradiation output at which complications occurred, initial time at which complications occurred and the physical status of the patients, such as visceral fat area. All patients with CR had significantly higher increased body temperature than the other patients. However, patients with progressive disease and 17 or more Hidaka output points showed significantly higher increased body temperature than patients with partial response or stable disease. Conclusions: Patients with CR had higher temperatures, but some patients with higher temperature also showed progressive disease. Further studies to examine the discrepancy between the clinical and histological response by using a large sample of surgically resected cases and to validate and reconfirm our findings are warranted.