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2 0 0 0 OA TRPM2 Contributes to Inflammatory and Neuropathic Pain through the Aggravation of Pronociceptive Inflammatory Responses in Mice.

著者
Haraguchi Kayo Kawamoto Ai Isami Kouichi Maeda Sanae Kusano Ayaka Asakura Kayoko Shirakawa Hisashi Mori Yasuo Nakagawa Takayuki Kaneko Shuji
出版者
Society for Neuroscience
雑誌
The Journal of neuroscience : the official journal of the Society for Neuroscience (ISSN:15292401)
巻号頁・発行日
vol.32, no.11, pp.3931-3941, 2012-03-14
被引用文献数
155
慢性痛の原因となる神経炎症応答の増悪機構を解明-新しい鎮痛薬開発の可能性-. 京都大学プレスリリース. 2012-03-15.

1 0 0 0 OA Developmental switching of perisomatic innervation from climbing fibers to basket cell fibers in cerebellar Purkinje cells.

著者
Ichikawa Ryoichi Yamasaki Miwako Miyazaki Taisuke Konno Kohtarou Hashimoto Kouichi Tatsumi Haruyuki Inoue Yoshiro Kano Masanobu Watanabe Masahiko
出版者
Society for Neuroscience
雑誌
The Journal of neuroscience : the official journal of the Society for Neuroscience (ISSN:15292401)
巻号頁・発行日
vol.31, no.47, pp.16916-16927, 2011-11-23
被引用文献数
50
In early postnatal development, perisomatic innervation of cerebellar Purkinje cells (PCs) switches from glutamatergic climbing fibers (CFs) to GABAergic basket cell fibers (BFs). Here we examined the switching process in C57BL/6 mice. At postnatal day 7 (P7), most perisomatic synapses were formed by CFs on to somatic spines. The density of CF-spine synapses peaked at P9, when pericellular nest around PCs by CFs was most developed, and CF-spine synapses constituted 88% of the total perisomatic synapses. Thereafter, CF-spine synapses dropped to 63% at P12, 6% at P15, and <1% at P20, whereas BF synapses increased reciprocally. During the switching period, a substantial number of BF synapses existed as BF-spine synapses (37% of the total perisomatic synapses at P15), and free spines surrounded by BFs or Bergmann glia also emerged. By P20, BF-spine synapses and free spines virtually disappeared, and BF-soma synapses became predominant (88%), thus attaining the adult pattern of perisomatic innervation. Parallel with the presynaptic switching, postsynaptic receptor phenotype also switched from glutamatergic to GABAergic. In the active switching period, particularly at P12, fragmental clusters of AMPA-type glutamate receptor were juxtaposed with those of GABA(A) receptor. When examined with serial ultrathin sections, immunogold labeling for glutamate and GABA(A) receptors was often clustered beneath single BF terminals. These results suggest that a considerable fraction of somatic spines is succeeded from CFs to BFs and Bergmann glia in the early postnatal period, and that the switching of postsynaptic receptor phenotypes mainly proceeds under the coverage of BF terminals.