著者
Ong Siew Mei Yamamoto Hiroki Saeki Kohei Tanaka Yuiko Yoshitake Ryohei Nishimura Ryohei Nakagawa Takayuki
出版者
Graduate School of Veterinary Medicine, Hokkaido University
雑誌
Japanese Journal of Veterinary Research (ISSN:00471917)
巻号頁・発行日
vol.65, no.1, pp.17-28, 2017-02

Numerous topoisomerase inhibitors with proven efficacy have been used extensively to treat various human neoplasms. However, among these, only doxorubicin has been used and studied extensively in veterinary oncology. The current study was performed to evaluate the responsiveness of canine osteosarcoma (cOSA), mammary gland tumour (cMGT), and malignant melanoma (cMM) cell lines to several topoisomerase inhibitors. In addition, the correlation between the sensitivity to treatment and multi-drug resistant (MDR) factors was investigated. cOSA cell lines exhibited higher sensitivity than cMGT and cMM cell lines to all the topoisomerase inhibitors tested in vitro; this was associated with the levels of multi-drug resistance protein 1 (MDR1) gene expression in the cOSA cell lines. Treatment of cOSA (HMPOS) and cMGT cell line (CHMp) xenograft mouse models with etoposide markedly delayed tumour progression in HMPOS xenografts, but failed to elicit lasting anti-tumour effects on CHMp xenograft mice. The present findings suggest that MDR1 represents a molecular signature for prediction of treatment efficacy of topoisomerase inhibitors, especially that of etoposide, which may be a clinically useful anti-tumour agent for cOSA; however, further study is necessary to refine the treatment protocol.
著者
Haraguchi Kayo Kawamoto Ai Isami Kouichi Maeda Sanae Kusano Ayaka Asakura Kayoko Shirakawa Hisashi Mori Yasuo Nakagawa Takayuki Kaneko Shuji
出版者
Society for Neuroscience
雑誌
The Journal of neuroscience : the official journal of the Society for Neuroscience (ISSN:15292401)
巻号頁・発行日
vol.32, no.11, pp.3931-3941, 2012-03-14
被引用文献数
154

慢性痛の原因となる神経炎症応答の増悪機構を解明-新しい鎮痛薬開発の可能性-. 京都大学プレスリリース. 2012-03-15.
著者
Miyake Takahito Nakamura Saki Zhao Meng So Kanako Inoue Keisuke Numata Tomohiro Takahashi Nobuaki Shirakawa Hisashi Mori Yasuo Nakagawa Takayuki Kaneko Shuji
出版者
Springer Nature
雑誌
Nature Communications (ISSN:20411723)
巻号頁・発行日
vol.7, 2016-09-15
被引用文献数
79

人はなぜ「冷たい」を「痛い」と感じるのか ―活性酸素と痛みセンサーTRPA1がカギを握る―. 京都大学プレスリリース. 2016-09-16.
著者
Nagashima Takuya Shirakawa Hisashi Nakagawa Takayuki Kaneko Shuji
出版者
Nature Publishing Group
雑誌
Scientific reports (ISSN:20452322)
巻号頁・発行日
vol.6, 2016-05-20
被引用文献数
41

有害事象ビッグデータから副作用の分子メカニズムを解明-統合失調症治療薬が起こす高血糖はビタミンDで防止できる. 京都大学プレスリリース. 2016-05-23.
著者
So Kanako Tei Yuna Zhao Meng Miyake Takahito Hiyama Haruka Shirakawa Hisashi Imai Satoshi Mori Yasuo Nakagawa Takayuki Matsubara Kazuo Kaneko Shuji
出版者
Nature Publishing Group
雑誌
Scientific Reports (ISSN:20452322)
巻号頁・発行日
vol.6, 2016-03-17
被引用文献数
34

「しびれ」による痛みのメカニズムを解明 -糖尿病や血流障害によるしびれ治療薬の開発に期待-. 京都大学プレスリリース. 2016-03-18.