著者

深井 孝之助 土佐 英輔 西 義美

出版者

日本ウイルス学会

雑誌

VIRUS (ISSN:18843425)

巻号頁・発行日

vol.1, no.2, pp.135-140, 1951-07-01 (Released:2010-03-16)

参考文献数

12

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Adsorption states of influenza virus, Lee strain, on chicken red cells were studied under electron microscope. Treating electronmicrographs quantitatively, adsorption end point was determined. From this end point, that the foundamental idea of CCA titration by Miller and Stanley had been fare, was proved. From some pictures, it was concluded that owing to agglutination of virus particles by antisera, the red cell agglutination inhibiton reaction would be caused. And virus particles adsorbed on chicken red cells were inversely eluted and agglutinated when anti-viral serum added after complete adsorption. This latter phenomenon was named as “robbing off reaction” by antisera.

著者

松井 千秋

出版者

日本ウイルス学会

雑誌

VIRUS (ISSN:18843425)

巻号頁・発行日

vol.2, no.2, pp.83-97, 1952-04-15 (Released:2010-03-16)

参考文献数

63

出版者

日本ウイルス学会

雑誌

VIRUS (ISSN:18843425)

巻号頁・発行日

vol.7, no.6, pp.430-448, 1957-12-25 (Released:2010-03-16)

著者

中村 清

出版者

日本ウイルス学会

雑誌

VIRUS (ISSN:18843425)

巻号頁・発行日

vol.4, no.3, pp.198-203, 1954-09-25 (Released:2010-03-16)

参考文献数

20

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It is the well established fact that after the recovery from the typical course of the Tsutsugamushi disease the patients acquire the solid immunity against it which was proved to last at least for a decade or thereover. However, in regard to the aspect of the immunity development in the case in which the disease was suppressed with antibiotics as soon as the specific symptoms became manifest, there remains much to be made clear.The author, in order to make this aspect clear, made some trials on human beings. Namely the patients of general paralysis, which had to receive the fever treatment, were infected with the inoculation of the virus of the Tsutsugamushi disease, Pescadores strain, of certain titer of mouse LD 50, and received the drug therapy with antibiotics to recovery at the various stadium of the disease. The investigation of the immunity development just mentioned was performed upon them. A part of the results obtained is presented preliminary in this paper as the first report. Namely it can be described summarily as follows.1. The experimental minimal infectious dosis (M. I. D) of the virus of the Tsutsugamushi disease to human beings is of approximate value to mouse LD 50 titer of it.2. Below the M. I. D., the virus cannot elicit the immunity development at all in the human body, althogh it had certainly invaded into it.3. The specific symptoms of the disease become just manifest when the invaded virus multiplied somewhere in the body to such an extent to elicit the rickettsiemia of approximately 10-2 LD 50.4. The patient is far more sensitive to the drug therapy with antibiotics at the height of the disease or still later than at the beginning of it.5. The specific reaction of the site of the skin, where the virus had certainly been inoculated, can sometimes be failed, though the inoculated person contracted the disease typically.6. A certain correlation can be observed between the length of duration of the disease and the degree of rise of OXK agglutinin titer.

著者

小西 俊造

出版者

日本ウイルス学会

雑誌

VIRUS (ISSN:18843425)

巻号頁・発行日

vol.2, no.4, pp.278-280, 1952-12-15 (Released:2010-03-16)

参考文献数

12

被引用文献数

1 1

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We tired to prevent measles with attenuated measles virus, which was obtained from patients and weakend by intratesticular passage through guinea pigs.The immunization was made by intranasal spraying for susceptible children.The results obtained were as follows:Classification of response Number ControlWith evidence 130 (33.8%) 156 (59.%)typical 12mild 81minimal 31no count 6No evidence 256 (66.2%) 106 (40.5%)with chance to be infectedfrom patients with measles 111no chance to be infectedfrom patients with measles 85not clear 60total 365 262A-significicant differece could be found between the results of the prevented and control groups.

著者

甲野 礼作 芦原 義守 榎本 知以子 松宮 恒夫 川上 勝朗 平山 宗宏

出版者

日本ウイルス学会

雑誌

VIRUS (ISSN:18843425)

巻号頁・発行日

vol.7, no.4, pp.223-233, 1957-08-20 (Released:2010-03-16)

参考文献数

41

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(1) From 1954 to 1956 the authors isolated 51 strains of cytopathogenic agents mostly from feces of patients with paralytic poliomyelitis using human embryonic skin-muscle tissue culture. As a result of typing we found 31 strains of type I (70%), 7 strains of type II (15%), 7 strains of type III (15%) and 6 untypable agents. 70 to 80 per cents of causative agents of paralytic poliomyelitis belonged to type I in Japan in the above period.(2) Neutralization test using 100 TCD 50 of three types of poliovirus vs. undiluted and diluted (1:10) sera from healthy individuals was done on 209 specimens from Tokyo. The percentage positive was lowest at 6-11 months after birth, increasing rapidly, and the adult level (80-100%) was reached about 4 to 6 years of age. This pattern of the age distribution of antibody is almost equal to those obtained in Cairo, Egypt, and French Morocco. In the case of diluted sera the final level attained was 60-80 per cent, so that about 20 per cent of immune adults were considered having antibody titer less than 1:10.(3) 46 per cent of paralytic polio occurred in the first year of life in Tokyo 1955, and steep increase of neutralizing antibody was seen among examinees belonging to the same age group. It means that paralytic sequelae are very likely to occur in the primary infection without protection of antibody.(4) Analysis of antibody for one or more types of poliovirus in various age groups shows that infection by any one type interfere with heterotypic infections, in other words there exists some degree of cross immunity between heterotypes.(5) Antibody titers of the pooled sera which were composed of an equal quantity of sera from individuals belonging to the same age group were minimum (antibody titer against type II and III were zero, but that of type I was 1:3 to 1:8) under one year of age, rose up to maximum (1:64 to 1:128) at 4 to 6 years of age, then declined a little and kept at a level (1:16 to 1:32) thereafter in Tokyo.

著者

波多野 基一

出版者

日本ウイルス学会

雑誌

VIRUS (ISSN:18843425)

巻号頁・発行日

vol.2, no.3, pp.187-194, 1952 (Released:2010-03-16)

参考文献数

29

被引用文献数

1 1

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(1) 日本脳炎ウィールスの新分離株 (計6株) は一定の条件下で孵化後24時間から3-4週迄の鶏雛血球を凝集させる.(2) 抽出された血球凝集素は易熱性であるが, 3,000 r.p.m. 20分遠沈上清として4℃保存で殆ど10,000 r.p.m. 60-90分遠沈上清と同じ程度安定に存し必ずしも高速遠心を必要としない.(3) 感染力を有するウィールス粒子と血球凝集素の関係につき吸收, Seitz濾過, 超遠心法, 不活化試験, メタノール精製法等で検討したが, 血球凝集素対LD50比の如きものに一定の関係は見出せず, 血球凝集素は少くもウィールス粒子自身ではない事をほぼ推定出来た.(猶本報告の要旨は昭和26年11月第5回日本細菌学会関東支部総会に於て報告した。)終りに貴重なウイールス株の御分与を忝うした予防衛生研究所安東清博士の御好意を深謝する。更に川喜田教授の御指導御鞭撻に謝意を表する。

著者

葛西 武雄

出版者

日本ウイルス学会

雑誌

VIRUS (ISSN:18843425)

巻号頁・発行日

vol.1, no.3, pp.175-186, 1951-10-10 (Released:2010-03-16)

参考文献数

98

著者

横田 強

出版者

日本ウイルス学会

雑誌

VIRUS (ISSN:18843425)

巻号頁・発行日

vol.5, no.1, pp.19-29, 1955-05-25 (Released:2010-03-16)

参考文献数

43

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1. An outbreak of epidemic myalgia prevailed among the employees in a company in Kawasaki in the summer of 1952. Many of the patients developed the clinical symptoms typical for epidemic myalgia but the remainders showed only fever and other uncharacterized symptoms.2. Precise clinical descriptions were made of some of the cases. They were almost typical for the usual epidemic myalgia.3. A strain of B group Coxsackie virus was isolated from a patient among them. This strain was serologically proved to belong to Bl of the classification by Dalldorf.4. It is very probable that this outbreak was caused by this type of Coxsackie virus.

出版者

日本ウイルス学会

雑誌

VIRUS (ISSN:18843425)

巻号頁・発行日

vol.6, no.3, pp.248-265, 1956 (Released:2010-03-16)