著者

田中 信介 渡辺 言夫 宮沢 博 芦原 義守

出版者

一般社団法人 日本感染症学会

雑誌

感染症学雑誌 (ISSN:03875911)

巻号頁・発行日

vol.56, no.7, pp.582-587, 1982

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妊婦145名についての風疹抗体測定を, 近年開発されキット化されたRUBEHSA<SUP>&reg;</SUP>を用いて行い, HIと比較した. また, 青年女子25名に風疹ワクチンを接種し, そのうち18名について抗体価を測定, その副反応も検討した.<BR>結果は, RUBELISA value 0.14以下を抗体陰性とすると, 抗体保有率は74.1%であった. HIでは23名が8倍未満で, 抗体保有率は84.7%であった. これら2方法の一致率は88.0%であり, 相関係数は0.85であった. 1977年秋の風疹ワクチン接種開始時すでに16歳以上であった予防接種対象外の者が現在妊娠可能年齢層となっており, いまだに妊婦の風疹感染の可能性が残されていると考えられた.<BR>青年女子のワクチン接種では8名32%に副反応を認め, すべてが関節症状を呈し, 関節痛6, 関節腫脹と痛み2であった. 抗体価は測定全例で上昇し, 平均HI価は25.1であった。年齢の高い女子の場合には, 副反応としての関節症状が重要であることが注目された.

著者

甲野 礼作 芦原 義守 榎本 知以子 松宮 恒夫 川上 勝朗 平山 宗宏

出版者

日本ウイルス学会

雑誌

VIRUS (ISSN:18843425)

巻号頁・発行日

vol.7, no.4, pp.223-233, 1957-08-20 (Released:2010-03-16)

参考文献数

41

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(1) From 1954 to 1956 the authors isolated 51 strains of cytopathogenic agents mostly from feces of patients with paralytic poliomyelitis using human embryonic skin-muscle tissue culture. As a result of typing we found 31 strains of type I (70%), 7 strains of type II (15%), 7 strains of type III (15%) and 6 untypable agents. 70 to 80 per cents of causative agents of paralytic poliomyelitis belonged to type I in Japan in the above period.(2) Neutralization test using 100 TCD 50 of three types of poliovirus vs. undiluted and diluted (1:10) sera from healthy individuals was done on 209 specimens from Tokyo. The percentage positive was lowest at 6-11 months after birth, increasing rapidly, and the adult level (80-100%) was reached about 4 to 6 years of age. This pattern of the age distribution of antibody is almost equal to those obtained in Cairo, Egypt, and French Morocco. In the case of diluted sera the final level attained was 60-80 per cent, so that about 20 per cent of immune adults were considered having antibody titer less than 1:10.(3) 46 per cent of paralytic polio occurred in the first year of life in Tokyo 1955, and steep increase of neutralizing antibody was seen among examinees belonging to the same age group. It means that paralytic sequelae are very likely to occur in the primary infection without protection of antibody.(4) Analysis of antibody for one or more types of poliovirus in various age groups shows that infection by any one type interfere with heterotypic infections, in other words there exists some degree of cross immunity between heterotypes.(5) Antibody titers of the pooled sera which were composed of an equal quantity of sera from individuals belonging to the same age group were minimum (antibody titer against type II and III were zero, but that of type I was 1:3 to 1:8) under one year of age, rose up to maximum (1:64 to 1:128) at 4 to 6 years of age, then declined a little and kept at a level (1:16 to 1:32) thereafter in Tokyo.