- 著者
- Keizo SAKAMOTO Futoshi SUGIMOTO Yoshisada SATO Etsuo FUJIMAKI Yoshihisa TASHIRO
- 出版者
- The Showa University Society
- 雑誌
- The Showa University Journal of Medical Sciences (ISSN:09156380)
- 巻号頁・発行日
- vol.11, no.4, pp.247-254, 1999 (Released:2010-09-09)
- 参考文献数
- 19
- 被引用文献数
- 6 6
This paper describes the theoretical background of Dynamic Flamingo Therapy (DF therapy) . DF therapy is a method based on Wolff's laws and Pauwels' lever arm theory for increasing the bone mineral density at the femoral neck. According to Pauwels' theory, during one-leg standing the femoral head receives 2.75 times the load applied during two-leg standing. Our photoelasticity results show that the maximum concentration of stress in the inner side of the femoral neck was 0.706kg/mm2 for the one-leg standing posture and 0.212kg/mm2 for the two-leg standing posture. When the patient stands on one leg the femur is subjected to a mechanical stress approximately 3-fold that of a normal standing posture without any increase in body weight. According to Peizer's walking cycle, 95% of the maximum stress applied to the femoral head of one leg (the supporting leg) equals 1.5/80 of the walking cycle. The time necessary to complete this number of cycles is 2987× (60/56) =3200 seconds (53.3minutes) .
- 著者
- John Chris CASTEL
- 出版者
- The Showa University Society
- 雑誌
- The Showa University Journal of Medical Sciences (ISSN:09156380)
- 巻号頁・発行日
- vol.16, no.3, pp.237-252, 2004 (Released:2010-09-09)
- 参考文献数
- 27
The purpose of this study was to determine if Patterned Electrical Neuromuscular Stimulation (PENS) and Medium Frequency Alternating Current (MFAC) would decrease the incidence of urinary incontinence (UI) in institutionalized elderly patients. The study subjects comprised 55 women (mean age of 85.14 years) who were residents of skilled nursing facilities. All patients received three, 20-minute PENS treatments per week for 6 weeks, applied to the T10-L2 paraspinal and suprapubic abdominal muscles as well as to the L1-2 and Sacral S2-S4 proximal medial thigh dermatomes and muscles. Additionally, 16 of the patients also received MFAC to the pelvic floor for 10 minutes immediately after the PENS treatment. We compared incidences of UI prior to and after the program in subjects who suffered from urge or mixed types of UI. On average, subjects in the PENS only group improved 73%, whereas subjects in the PENS and MFAC group improved 66%. Overall, 92% of the patients reported satisfaction with the incontinence program and would recommend this treatment to others who are incontinent. The follow-up progress notes of 18 patients were reviewed 4 weeks post discharge and only one patient did not maintain the improved status. Both PENS and MFAC are effective in treating patients with UI. PENS achieves the neuromuscular re-education of the pelvic muscle complex and modulates the urge sensation ; whereas MFAC is used to strengthen the pelvic floor and sphincter muscles.
- 著者
- Yoshito MIYATA Shin OHTA Akihiko TANAKA Kaho AKIMOTO Hiroki SATO Tomoki UNO Haruna SATO Yoshitaka UCHIDA Megumi JINNO Kuniaki HIRAI Hideki INOUE Tetsuya HONMA Mayumi YAMAMOTO Shintaro SUZUKI Hironori SAGARA
- 出版者
- The Showa University Society
- 雑誌
- The Showa University Journal of Medical Sciences (ISSN:09156380)
- 巻号頁・発行日
- vol.32, no.4, pp.247-256, 2020 (Released:2021-01-28)
- 参考文献数
- 28
Mepolizumab is a monoclonal antibody against interleukin-5 used for the treatment of severe asthma. The effect of long-term mepolizumab administration and its persistence in clinical practice is poorly understood. Thus, this study aimed to investigate the effect of long-term administration of mepolizumab in patients with severe asthma. Mepolizumab was administered to 20 patients with severe asthma. We then prospectively followed the patients for 104 weeks to investigate the efficacy of long-term mepolizumab administration in clinical practice. Eleven patients were evaluated for 104 weeks. Mepolizumab administration reduced asthma exacerbations in a year from 52 to 104 weeks and improved asthma control in every period as assessed by questionnaires. Also, blood eosinophil counts decreased at every point, and blood basophil counts decreased at 104 weeks. We compared various parameters among the 11 patients who continued administration for more than 104 weeks and 7 patients who discontinued treatment due to ineffectiveness. Significant differences were observed in disease duration, maximum expiratory flow at 50%, and blood basophil count. Long-term mepolizumab administration improved asthma symptoms in patients with severe asthma and reduced the frequency of exacerbations.
- 著者
- Naomi Kobinata Hideto Yoshikawa Yuji Iwasaka Nobuyuki Kawate
- 出版者
- The Showa University Society
- 雑誌
- The Showa University Journal of Medical Sciences (ISSN:09156380)
- 巻号頁・発行日
- vol.33, no.2, pp.34-40, 2021 (Released:2021-06-15)
- 参考文献数
- 28
This retrospective study aimed to investigate the relationship between musical and linguistic abilities in patients with aphasia. We reviewed the clinical records of 32 stroke patients with aphasia admitted to subacute rehabilitation units between May 2014 and August 2018. We analyzed the results of melody and rhythm reproduction tests and subtests of auditory comprehension and speech sections in the Standard Language Test of Aphasia (SLTA) collected upon admission and discharge. The Spearman rank correlation coefficient (rs) was used to analyze the correlation between 1)the increase in melody reproduction test scores and SLTA auditory comprehension subtest scores, 2)the increase in melody reproduction test scores and SLTA speech subtest scores, 3)the increase in rhythm reproduction test scores and SLTA auditory comprehension subtest scores, and 4)the increase in rhythm reproduction test scores and SLTA speech subtest scores. There were significant positive correlations between melody reproduction and auditory comprehension subtest scores on the SLTA: “word comprehension” (n=14, rs=0.57, p<0.05) and “following verbal instructions” (n=31, rs=0.42, p<0.05). An SLTA speech subtest score—action naming—was positively correlated with rhythm reproduction (n=31, rs=0.44, p<0.05). This study implies that melody reproduction ability is related to auditory comprehension and that rhythm reproduction ability is related to speech production in patients with aphasia after experiencing a stroke.
- 著者
- KUSAMA Kazushige NOZU Fumihiko AWAI Toshinari TANAKA Shigeki HONMA Ikuo MITAMURA Keiji
- 出版者
- 昭和大学学士会
- 雑誌
- The Showa University Journal of Medical Sciences (ISSN:09156380)
- 巻号頁・発行日
- vol.15, no.2, pp.109-117, 2003
We evaluated the role of the Rho effector, ROCK in caeruleininduced acute pancreatitis. To induce acute pancreatitis, caerulein, a CCK (Cholecystokinin) analogue was injected intraperitoneally (IP) every hour for six h, and ROCK-II specific inhibitor, Y-27632, was injected three times by IP 4.5, 6.5, and 8.5 h after the first injection of caerulein. The pancreatic weight ratio did not change significantly in response to either 20μg/kg caerulein alone or a combination of 20μg/kg caerulein and 3 or 30 mg/kg Y-27632. By 12 h after the IP injection of 20μg/kg caerulein and the combination 20μg/kg caerulein and 3 mg/kg Y-27632, the levels of serum amylase increased by 2- to 3-fold over the zero time level. The levels returned to normal by 24 h. Between 9 and 24 h after the combined injection of 20μg/kg caerulein and 30 mg/ kg Y-27632, the levels of serum amylase increased significantly by 5-fold over the zero time and recovered to normal levels by 168 h. Interstitial edema was observed 7 h after the initial IP injection but diminished by 168 h. Mild changes in vacuolization, cell infiltration, and necrosis were observed initially, although these conditions reverted to normal within 168 h. Our data suggest that ROCK-II mediates pancreatic enzyme secretion and prevents acute pancreatitis.
- 著者
- Yukio HATTORI Rieko NEMOTO Akira KANDA Takeshi KAWAGUCHI
- 出版者
- The Showa University Society
- 雑誌
- The Showa University Journal of Medical Sciences (ISSN:09156380)
- 巻号頁・発行日
- vol.14, no.4, pp.281-291, 2002 (Released:2010-09-09)
- 参考文献数
- 22
We investigated the epidemiological relationship between the personality styles of Japanese women and their eating habits and behaviors. We conducted a cross-sectional study on 157 female students in the nutritionist vocational school A in Tokyo, Japan. Participants answered questions relating to personality style and daily food intake and underwent physical and biochemical investigations. Multivariate analysis of lifestyle-related factors revealed a significant positive correlation between the personality type that tended to lose patience and overeating, and between the ‘internal-type’ score on the multiple health locus of control (MHLC) scale and energy intake. The ‘chance-type’ score was negatively correlated with exercise habit, and the ‘power-type’ score was positively correlated with the overeating score and the frequency of eating breakfast. The personality predisposition of the internal-type is to “control my own health by myself”, the opposite to that of the power-type, which is to “leave my health to specialists”. The internal-type and the power-type showed opposing trends in all lifestyle-related indices except for the frequency to eat breakfast. This study suggests that these personality predispositions are closely correlated with eating habits. Dietary advice should be given while paying sufficient attention to the personality predisposition of individual subjects.
- 著者
- Yukiko SHOUJI Chika HASEGAWA Xiao-Pen LEE Masaya FUJISHIRO Takaaki MATSUYAMA Miho YAMADA Ayako KURIKI Yuka KATO Noriko NEMOTO Takeshi KUMAZAWA Shinichi SUZUKI Keizo SATO
- 出版者
- The Showa University Society
- 雑誌
- The Showa University Journal of Medical Sciences (ISSN:09156380)
- 巻号頁・発行日
- vol.30, no.2, pp.175-187, 2018 (Released:2018-08-31)
- 参考文献数
- 33
- 被引用文献数
- 1
A high-throughput method was developed to analyze five barbiturates (phenobarbital, cyclobarbital, amobarbital, secobarbital, and thiopental) and a metabolite in human body samples using a new Monolithic C18 gel-packed Spin Tip and ultra-performance liquid chromatography (UPLC)-quadrupole-time-of-flight (Q-ToF) mass spectrometry (MS). Plasma (20µl) or urine (100µl) samples spiked with the five barbiturates and 5-(4-methylphenyl)-5-phenylhydantoin (internal standard, IS) were mixed with distilled water. The mixture was extracted using the Monolithic C18 Spin Tip, and the analytes retained on the C18 phase were then eluted with methanol. The eluate was injected directly into an analytical column (Waters Acquity BEH C18, 50mm×2.1mm i.d., particle size 1.7µm), and quantified by Q-ToF-MS with negative-ion electrospray ionization (ESI). Good separation and clear peak shapes of the five drugs were achieved within an analysis time of 6min, including the extraction time. All drugs spiked in the plasma showed recoveries of 86-98%. The regression equations for the five drugs showed excellent linearities in the range of 5-500ng/20µl of plasma, with limits of detection and i-Fit of 1ng/20µl. The method was also successfully applied to determine the level of amobarbital and its metabolite in human plasma and urine, respectively, after oral administration to a volunteer. This new method could be applied widely in the clinical and forensic fields for the quantitative determination of drugs and metabolites.
- 著者
- MINEMURA Atsuko HOSOI Misa TANAKA Katsumi HIROSHIGE Jyuichi ARUGA Tohru MURAYAMA Jun-Ichiro
- 出版者
- The Showa University Society
- 雑誌
- The Showa University Journal of Medical Sciences (ISSN:09156380)
- 巻号頁・発行日
- vol.16, no.1, pp.55-63, 2004
A database which allows bi-directional communication between an emergency room (ER) and a department of pharmacy services was developed to facilitate the rapid treatment of patients with life-threatening exposure to toxic substances. Accurate information regarding the substances involved is essential for effective treatment. These substances may be prescription drugs or may be of domestic origin such as washing detergents or herbicides. Microsoft<SUP>®</SUP> Access 2000 was employed as the database software to store patient records from 1995 to 2001. For cases involving intoxication or poisoning, the data fields were as follows : the date and time, the estimated period of exposure, ingestion mode, the suspected toxic materials, classification of drugs, and electrocardiogram. To maximize ease of use, information could be entered via a dialog screen. Live access was always maintained for both facilities, ieonce data had been entered in the database, it could be immediately accessed from either the pharmacy division or the ER. To protect patient confidentiality, only the patient's identification number was entered. The database itself was protected by password access. Major advantages of this system are that it can be online 24 hours per day and it will reduce the time involved in transferring information from the pharmacy services to ER.