著者
若林 一郎
出版者
Osaka Urban Living and Health Association
雑誌
生活衛生 (ISSN:05824176)
巻号頁・発行日
vol.48, no.1, pp.387-395, 2004 (Released:2005-01-27)
参考文献数
60
被引用文献数
1
著者
Tetsuo YAMANO
出版者
Osaka Urban Living and Health Association
雑誌
SEIKATSU EISEI (Journal of Urban Living and Health Association) (ISSN:05824176)
巻号頁・発行日
vol.50, no.5, pp.359-364, 2006 (Released:2006-10-19)
参考文献数
17

Allergic contact dermatitis is an important and common health problem. It is known that the large number of chemicals used in household products, including biocides, dyes, rubber-accelerators, solvents, and UV-absorbers, have the inherent potential to cause skin sensitization. With cases of allergic contact dermatitis being reported constantly in many countries, the need for precise criteria is clear. In order to prevent the adverse health effects caused by exposure to skin-sensitizing chemicals, it is essential as a first step to identify sensitizing chemicals and quantitatively evaluate their potency. Such data have been obtained from animal experiments, especially with guinea pigs and mice. However, recent progress in computer technologies and mounting demands for priority to animal welfare have made it necessary to include other methods such as in silico prediction of quantitative structure-activity relationships and in vitro methods using cultured immunocytes. In the present article, recent methods of evaluating skin-sensitizing chemicals and of applying the data in the risk management process are reviewed.