著者
Toru Takano
出版者
(社)日本内分泌学会
雑誌
Endocrine Journal (ISSN:09188959)
巻号頁・発行日
pp.EJ17-0026, (Released:2017-02-02)
被引用文献数
11

Thyroid cancers have long been considered to arise in middle age and, after their repeated proliferation, resulting in further damage to the genome, they progress to more aggressive and lethal cancers. However, in 2014, some studies were reported that might lead to a marked change in our understanding of the natural history of thyroid cancer. A high prevalence of papillary carcinoma in the young suggested that the first initiation of thyroid cancer is likely to occur in the infantile period. Such a conclusion was also supported by a very slow growth rate of papillary microcarcinomas (PMCs) in an observation trial. The proliferation rate of PMCs was negatively correlated with the age, and surgery to remove PMCs did not contribute to reduce mortality from thyroid cancer. These findings strongly suggested the existence of self-limiting cancers, which are truly malignant but do not progress to lethal cancers, for the first time in human history. The early detection of self-limiting cancers results in overdiagnosis. Ultrasonographic screening of the thyroid in the young should be avoided. Lethal thyroid cancers, whose origin is still unknown, appear suddenly after middle age. In the elderly, thyroid cancers are a mixture of self-limiting and lethal cancers; thus, when thyroid cancer is detected, careful follow-up with examination of its growth rate is required.

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外部データベース (DOI)

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高野徹「甲状腺がんの自然史」(英文) https://t.co/EWzwRoeZZs まとめ部分の和訳 https://t.co/ZbRDwGhx8b
見つけるのに時間が掛かってしまいました。「Natural history of thyroid cancer」https://t.co/hb1y5AbN7e で合っていますか? https://t.co/68xb9wrHaL
あっちゃん、症状のない子ども達に甲状腺検査を行うとこの方達を見つけることになるって知ってる? 論文 : https://t.co/SCbSSpZqAQ https://t.co/QieFMp8M2i @masanoatsuko @llERihhimjdUBY4
症状のない子ども達に甲状腺検査を行うとこの方達を見つけることに 高野徹・甲状腺がんの自然史[レビュー] 2017/02/02 : https://t.co/SCbSSpZqAQ 【Fig. 2 検死解剖で検出された甲状腺がん】 https://t.co/QieFMp8M2i
Natural history of thyroid cancer [Review]  https://t.co/TvGkWLFbx5  https://t.co/ISchwhhi5h
ほう、 大阪大学大学院医学系研究科 甲状腺腫瘍研究チーム:https://t.co/S8XpQj1BPY 高野徹・甲状腺がんの自然史[レビュー] 2017/02/02 : https://t.co/SCbSSpZqAQ 【Fi… https://t.co/lqvYfXzT7R
1 1 https://t.co/7qIsy9Qunp
Natural history of thyroid cancer [Review] https://t.co/AT2ZIFUT3V (Predicted outcome of the Fukushima Health Manag… https://t.co/WttbO2iVho

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