著者
丹羽 浩子 田辺 公一 矢野 玲子 後藤 伸之 大津 史子
出版者
一般社団法人 日本医薬品情報学会
雑誌
医薬品情報学 (ISSN:13451464)
巻号頁・発行日
vol.20, no.3, pp.145-155, 2018-11-30 (Released:2018-12-08)
参考文献数
26

Objective:In this study,we explored adverse reactions and patient background and performed a case/non-case study on a database of adverse reaction case reports in order aid the prevention of non-prescription drug abuse.Study Design:We conducted a case/non-case study on a database of adverse reaction case reports.Methods:We studied case reports of adverse reactions and addiction in Japan and extracted adverse reaction cases associated with taking antipyretic analgesics,antitussive drugs,antitussive expectorant drugs,hypnotic and sedative drugs,anti-anxiety drugs,and purgative drugs. We divided the extracted cases into an abuse case group (adverse reactions associated with non-prescription drug abuse,and divided its intended purpose or the purpose of abuse at the initial dose)and non-case group(other adverse reactions). We performed univariate logistic regression analysis on each item of investigation in the abuse case group and non-case group and calculated the odds ratio,p-value,and 95%confidence interval.Results:There were many abuse case reports of women 20-40 years old in the antipyretic analgesics abuse case group and many of them had liver/biliary lesions and chronic urological impairment. The most common reason reported for taking the initial dose of each drug was for its intended purpose.Discussion:It is important for pharmacists at community pharmacies and drugstores to be able to recognize the characteristics of patients who might be at risk of abuse and the adverse reactions and patient backgrounds elucidated in this study could be helpful in identifying them.

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【医療関係者向け参考情報】 ‘I can't be an addict. I am.’ Over-the-counter medicine abuse: a qualitative study https://t.co/oVjQ0CRB0V 薬物関連精神疾患の実態調査https://t.co/26PV8CI8nP 一般用医薬品の乱用による副作用の実態https://t.co/kO4BLyzz6R
市販薬依存に関する大変有意義な研究があったのでシェアします。めちゃくちゃ貴重です。平さんの論文(@hayamichou)も引用されてました。 一般用医薬品の乱用による副作用の実態と患者背景との関連性に関する研究 https://t.co/kO4BLyzz6R
名城大学薬学部医薬情報センターの副作用と中毒に関する報告を集めたデータベースCARPISを使用 【医薬品情報学】 一般用医薬品の乱用による副作用の実態と患者背景との関連性に関する研究 https://t.co/XfS9mIO5uw
J-STAGE Articles - 一般用医薬品の乱用による副作用の実態と患者背景との関連性に関する研究 https://t.co/Id7NyXXvjM

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