著者
嵯峨井 勝 ウィンシュイ ティンティン
出版者
一般社団法人日本衛生学会
雑誌
日本衛生学雑誌 (ISSN:00215082)
巻号頁・発行日
vol.70, no.3, pp.220-229, 2015 (Released:2015-09-26)
参考文献数
47
被引用文献数
4 4

Traffic-related air pollution is a major contributor to urban air pollution. Diesel exhaust (DE) is its most important component of near-road and urban air pollutions and is commonly used as a surrogate model of air pollution in health effects studies. In particular, diesel exhaust particles (DEPs) and nanoparticles in DEPs are the components considered hazardous for health. It is widely known that exposure to DEPs is associated with mortality caused by respiratory and cardiovascular diseases. Recently, evidence has been accumulating showing that DEPs and nanoparticles may cause neurodegenerative disorders. Here, we introduce evidence suggesting their association with these disorders. The chemical components and the translocation of DEPs and nanoparticles to the brain are described in part 1. In part 2, we introduce the mechanism of development of neurodegenerative diseases such as stroke, Alzheimer’s disease, and Parkinson’s disease via oxidative stress and inflammatory events. Furthermore, there are many lines of epidemiological evidence showing that the particulates impair cognitive function and ability of memory through oxidative and inflammatory events in the brain. These lines of evidences are supported by many animal experiments on neurological disorders.

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大気中微小粒子状物質(PM2.5)から生じる 酸化ストレスと脳神経障害 4 章.大気中微小粒子が脳神経系に及ぼす人に関する疫学研究 4.1. 子供や若齢者の記憶・学習能に及ぼす影響 4.5. 人の臭覚に及ぼす影響 など https://t.co/mHdnRvtXxG

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