著者
宇田川 潤 日野 広大
出版者
一般社団法人日本衛生学会
雑誌
日本衛生学雑誌 (ISSN:00215082)
巻号頁・発行日
vol.71, no.3, pp.188-194, 2016 (Released:2016-09-30)
参考文献数
47
被引用文献数
2 4

Epidemiological studies suggest that exposure to prenatal stressors, including malnutrition, maternal immune activation (MIA), and adverse life events, is associated with increased risks of schizophrenia, autism spectrum disorder (ASD), and attention-deficit hyperactivity disorder (ADHD). However, the underlying pathophysiological mechanisms are unclear. The first trimester of pregnancy is particularly a vulnerable period. During this period, the self-renewal of neural stem cells and neurogenesis vigorously occur, and synaptic connections are partially formed in the telencephalon. Disturbance of this neuronal proliferation and migration during the first trimester may underlie the increased susceptibility to these disorders. Epigenetic modifications, such as DNA methylation and histone modification, are critical mechanisms for regulating gene expression. They can be affected by stress and are associated with an increase in susceptibility to schizophrenia and developmental disabilities. Injection of polyinosinic–polycytidylic acid or lipopolysaccharide induces MIA, enhances the expression of proinflammatory cytokines, and leads to the activation of microglia and the subsequent epigenetic modification of neurons or glia in the offspring. Furthermore, maternal high-fat diet and obesity similarly induce MIA and therefore may increase the risk of developmental disabilities. In addition, maternal stress reprograms the hypothalamic–pituitary–adrenal (HPA) axis, which regulates the stress response in the offspring. Thus, exposure to prenatal stress may increase the susceptibility to schizophrenia, ASD, or ADHD in the offspring through epigenetic modifications, MIA, and alteration of the HPA axis.

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https://t.co/8nCKkY4YYC 2016年に出されているこの文書。自覚症状と身に覚えがある、もしくはその可能性を大いに秘めていると感じて凄く気になっている。
@ForYourInforma 発達障害正式には 神経発達障害 胎児期に母体がストレスを感じると 胎児の脳神経の発達が障害される 『妊娠期の母体ストレスと 脳機能形成異常』 https://t.co/lg9UAtVeAQ
人の幸福感を規定するのは ほとんど 『母胎に居る時 母親がストレスを 強く感じたかどうか』で 子の幸福感を決めるんだと思う https://t.co/lg9UAtVeAQ

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