著者
木村 公美 三橋 真由美 奈良輪 知也 尾鳥 勝也 矢後 和夫 伊藤 智夫
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.38, no.12, pp.751-756, 2012-12-10 (Released:2013-12-10)
参考文献数
11
被引用文献数
2 2

The simple suspension method has been developed for performing tubal administration by placing tablets or capsules in hot water (55 °C) and serially decaying/suspending them without crushing/opening them. However, the stability of a cardinal drug against the pH of the suspension and heat remains unclear. In this study, we examined the stability of an oral anti-tumor preparation, capecitabine tablets, against the pH of the suspension and heat. Initially, we assessed the stability of capecitabine tablets suspended in phosphate-buffered saline at various pHs. Subsequently, we investigated the stability of capecitabine tablets suspended in phosphate-buffered saline heated at 25 or 55 °C. In addition, we evaluated the stability of this preparation heated at 55 or 80 °C for 30 minutes after being suspended in phosphate-buffered saline heated at 25 °C. When capecitabine suspension was heated at 80 °C for 30 minutes under acidic conditions, the residual capecitabine rate was approximately 50%. Then, a tube passage test of capecitabine was conducted. Passage was favorable. There was no decrease in the content after passage in comparison with the pre-passage value. Based on these results, the tubal administration of capecitabine should be performed considering both the drug suspension pH and temperature.

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外部データベース (DOI)

Yahoo!知恵袋 (1 users, 1 posts)

ちゃちゃ入れるつもりはありませんが。 「プロドラッグなので~」というのは間違いです。 例えば、腸溶性製剤などは、腸で溶けるようにコーティングしてあるため粉砕はできません。コーティングが外れてしまいますから。 ただ、ゼローダは酵素による分解における話ですので、粉砕はして構いません。では、なぜ調剤薬局などで粉砕しないのか。抗がん剤は粉砕しないんです。それは、かなり粉砕すると、本当に小麦粉の ...

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