著者

横山 真貴子 上野 由利子 長谷川 かおり キムラ クミ イシダ アキコ ハラダ マチコ 横山 真貴子 上野 由利子 長谷川 かおり 木村 公美 石田 晶子 原田 真智子 YOKOYAMA Makiko UENO Yuriko HASEGAWA Kaori KIMURA Kumi ISHIDA Akiko HARADA Machiko

出版者

奈良教育大学教育学部附属教育実践総合センター

雑誌

教育実践総合センター研究紀要 (ISSN:13476971)

巻号頁・発行日

no.18, pp.23-32, 2009-03

著者

木村 公美 三橋 真由美 奈良輪 知也 尾鳥 勝也 矢後 和夫 伊藤 智夫

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.38, no.12, pp.751-756, 2012-12-10 (Released:2013-12-10)

参考文献数

11

被引用文献数

2 3

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The simple suspension method has been developed for performing tubal administration by placing tablets or capsules in hot water (55 °C) and serially decaying/suspending them without crushing/opening them. However, the stability of a cardinal drug against the pH of the suspension and heat remains unclear. In this study, we examined the stability of an oral anti-tumor preparation, capecitabine tablets, against the pH of the suspension and heat. Initially, we assessed the stability of capecitabine tablets suspended in phosphate-buffered saline at various pHs. Subsequently, we investigated the stability of capecitabine tablets suspended in phosphate-buffered saline heated at 25 or 55 °C. In addition, we evaluated the stability of this preparation heated at 55 or 80 °C for 30 minutes after being suspended in phosphate-buffered saline heated at 25 °C. When capecitabine suspension was heated at 80 °C for 30 minutes under acidic conditions, the residual capecitabine rate was approximately 50%. Then, a tube passage test of capecitabine was conducted. Passage was favorable. There was no decrease in the content after passage in comparison with the pre-passage value. Based on these results, the tubal administration of capecitabine should be performed considering both the drug suspension pH and temperature.