- 著者
-
青野 要
山本 道夫
飯田 荘介
内海 耕慥
- 出版者
- 岡山医学会
- 雑誌
- 岡山医学会雑誌 (ISSN:00301558)
- 巻号頁・発行日
- vol.90, no.9-10, pp.1297-1308, 1978-10-30 (Released:2009-08-24)
- 参考文献数
- 36
- 被引用文献数
-
1
In relation to the mechanism by which hemolysis was induced in radiated human erythrocytes in vitro, several inducements of membrane lipid peroxidation and protective effects of V. E and SOD were investigated. Results obtained were as follows:(1) K+-release from erythrocytes was accelerated by radiation prior to hemolysis. These accelerated hemolysis and K+-release were protected remarkably by V. E and evidently by SOD.(2) Mitochondrial Fe2+ induced and Fe3+-O2 generating system - ADP induced lipid peroxidation, and microsomal O2 generating system - induced lipid peroxidation were also protected by V. E and SOD.(3) Radiation of X-ray or 60Co γ-ray accelerated lipid peroxidation of liver homogenate, microsome and liposome. Some of these accelerated lipid peroxidations were protected effectively by V. E and SOD.These results suggest that O2 and/or OH·generation by radiation induces of membrane lipid peroxidation, which leads deterioration of membrane resulting in the change of ion permeability and then hemolysis.