著者
Masashi TAKAHASHI Yuko GOTO-KOSHINO Kenjiro FUKUSHIMA Hideyuki KANEMOTO Ko NAKASHIMA Yasuhito FUJINO Koichi OHNO Yasuyuki ENDO Hajime TSUJIMOTO
出版者
公益社団法人 日本獣医学会
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.13-0345, (Released:2014-02-10)
被引用文献数
2

Nimustine (ACNU) is an alkylating agent of the nitrosourea and can be an antineoplastic agent in dogs. But, there has been no report on its dose-limiting toxicity (DLT) in dogs. This study was a phase I dose-escalation clinical trial to determine the maximum tolerated dose (MTD) and DLT of ACNU in tumor-bearing dogs. The starting dosage was 25 mg/m2, and subsequent dosages were administered in increments of 5 mg/m2 in cohort of 3 dogs. Eight dogs were included and the MTD was determined to be 25 mg/m2, DLT was neutropenia and the optimal interval was considered to be 21 days. The data herein provides a basis for the subsequent phase II trial of ACNU in dogs.

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外部データベース (DOI)

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Phase I Dose-Escalation Study of Nimustine in Tumor-Bearing Dogs https://www.jstage.jst.go.jp/article/jvms/advpub/0/advpub_13-0345/_article 

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Phase I Dose-Escalation Study of Nimustine in Tumor-Bearing Dogs https://t.co/geClmLxHiZ
dog #nimustin maximum tolerated dose determined to be 25 mg/m2 http://t.co/DJH1ldwx0y

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