著者

竹山 勇 漆畑 保 堤 康一朗

出版者

日本喉頭科学会

雑誌

喉頭 (ISSN:09156127)

巻号頁・発行日

vol.5, no.1, pp.6-11, 1993-06-01 (Released:2012-09-24)

参考文献数

14

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A marked difference in the incidence of laryngeal carcinoma between male and female has been widely unknown. The reason to this, however, has been unknown. In this connection, the affinity of the laryngeal tissue for androgen hormone was investigated in the present study. An auto radio-graphic study was conducted with the tissue of normal laryngeal mucosa and that of moderately differentiated squamous cell carcinoma of the larynx. 3H-T and its metabolites were found in the nuclei of epithelial cells of male vocal folds and some parts of male laryngeal carcinoma tissues. This suggest the existence of some effect of testosterone on the cell nuclei of these tissues. Quantitative analyses of the intracellular distribution of radioactivity conducted by means of the silver grain counting method showed that approximately 60-70% of 3H-T were located in the nuclear compartment of cancer cells of small size and the epithelium of the vocal fold near the basement membrane. The ABC method demonstrated a positive reaction in the nuclei of laryngeal carcinoma cells and the laryngeal muscle in males.These findings suggest that human laryngeal tissue, especially the vocal fold tissue, and laryngeal carcinoma cells may be one of the target organs for androgenic steroids and that androgen plays an important role in the carcinogenetic process of normal laryngeal tissue.