著者
坂口 修平
出版者
公益社団法人 日本薬学会
雑誌
YAKUGAKU ZASSHI (ISSN:00316903)
巻号頁・発行日
vol.124, no.2, pp.69-87, 2004-02-01 (Released:2004-01-28)
参考文献数
77
被引用文献数
5 5

Despite the remarkable progress in intensive care medicine, sepsis and shock continue to be major clinical problems in intensive care units. Septic shock may be associated with a toxic state initiated by the stimulation of monocytes by bacterial toxins such as endotoxin, which is released into the bloodstream. This study describes the role of oxidative stress in endotoxin-induced metabolic disorders. We demonstrate that endotoxin injection results in lipid peroxide formation and membrane injury in experimental animals, causing decreased levels of free radical scavengers or quenchers. Interestingly, it was also suggested that tumor necrosis factor (TNF)-induced oxidative stress occurs as a result of bacterial or endotoxin translocation under conditions of reduced reticuloendothelial system function in various disease states. In addition, we suggest that intracellular Ca2+, Zn2+, or selenium levels may participate, at least in part, in the oxidative stress during endotoxemia. On the other hand, it is also suggested that the extent of endotoxin-induced nitric oxide (NO) formation may be due, at least in part, to a change in heme metabolic regulation during endotoxemia. However, in our experimental model, NO is not crucial for lipid peroxide formation during endotoxemia. Sho-saiko-to is one of the most frequently prescribed Kampo medicines and has primarily been used to treat chronic hepatitis. We report that Sho-saiko-to decreases the rh TNF-induced lethality in galactosamine-hypersensitized mice and protects mice against oxygen toxicity and Ca2+ overload in the cytoplasm or mitochondria during endotoxemia. We further suggest that Sho-saiko-to shows a suppressive effect on NO generation in macrophages stimulated with endotoxin and that it may be useful in improving endotoxin shock symptoms.

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筆者らは長年,ショックモデルとしてのエンドトキシン血症の病態生理学の研究に興味を持っていた 敗血症性ショックモデルとしてのエンドトキシンの病態生理 ―酸化ストレスからのアプローチ― https://t.co/rQdiuEJE01
エンドトキシンで惹起される酸化ストレス→過酸化脂質。 肝臓、腎臓、肺にダメージ。 そしてエンドトキシン血症で亜鉛欠乏。 メタロチオネイン気になる。この3分の1がシステインだもんなぁ。 敗血症性ショックモデルとしてのエンドトキシンの病態生理 https://t.co/rQdiuEJE01 https://t.co/uUdFdwIHpc

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