著者
舩田 正彦 富山 健一
出版者
公益社団法人 日本薬学会
雑誌
YAKUGAKU ZASSHI (ISSN:00316903)
巻号頁・発行日
vol.140, no.2, pp.205-214, 2020-02-01 (Released:2020-02-01)
参考文献数
58

Cannabis use among the younger population in Japan has been steadily increasing. The aim of the present review is to highlight recent knowledge regarding the molecular mechanisms of action and health risks associated with cannabis and synthetic cannabinoid consumption. We investigated the effects of Δ9-tetrahydrocannabinol (THC) and synthetic cannabinoids on place conditioning in ICR mice. Both Δ9-THC and synthetic cannabinoids produce a significant conditioned place preference. These rewarding effects were completely suppressed by the cannabinoid CB1 receptor type antagonist AM251. The cytotoxicological effects of Δ9-THC and synthetic cannabinoids were also characterized in the limbic forebrain of mice in primary culture in vitro. Δ9-THC and synthetic cannabinoids caused cell death in a dose-dependent manner. The rank order of cytotoxicological potency was synthetic cannabinoids>Δ9-THC and related to the agonistic activities of the CB1 receptor. A recent review on the harmful effects of cannabis use in humans reported that behavioral impairments, especially in terms of attention, memory, and complex information-processing ability, can last for many weeks after cessation of cannabis use among heavy users. In addition, cannabis use could be a risk factor for drug dependence and later psychosis among adolescents. The results of animal and human studies suggest that CB1 receptors play an important role in the expression of harmful effects of cannabis and synthetic cannabinoid use. Moreover, concern regarding increasing concentrations of Δ9-THC in cannabis in many countries has been noted, because more potent cannabis may be associated with worse adverse effects.

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外部データベース (DOI)

Twitter (7 users, 8 posts, 16 favorites)

なんつーか逮捕者が出るたびに擁護者が湧いてきて毎度思うが全然無害じゃないし、同じ名称でも近年は、成分量が増加傾向にあるそうなので、駄目ゼッタイだと思う。 https://t.co/iya091vU2e
@gjmorley @MichikoKameishi 大麻乱用による気分の高揚や 多幸感から大麻乱用が止まらなくなり,覚せい剤や 麻薬と同様に精神依存に陥ることが報告されてい る. https://t.co/J41KfTT8l7
@yamattad 他の論文にもTHCのリスクが書かれて いたわ。依存性と脳の萎縮。 THCは医療用大麻にも使用されている。 https://t.co/fbuAzAGxnL https://t.co/Y4N7TNdIDT

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