著者

山本 郁男

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.106, no.7, pp.537-561, 1986-07-25 (Released:2011-01-31)

参考文献数

117

被引用文献数

10 9

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The review on our recent works mainly consists of four parts in relation to biochemical pharmacology and toxicology, and metabolism of marihuana constituents, tetrahydrocannabinol as follows; 1) metabolic activation, 2) interactions with other central acting drugs, 3) development of tolerance and cross-tolerance, 4) other biological effects.Especially, the role of the active metabolites of tetrahydrocannabinol in the marihuana intoxication has been discussed in detail.