著者

藤本 正治

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.57, no.5, pp.374-381, 1999-05-01 (Released:2009-11-16)

参考文献数

9

被引用文献数

2 3

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Cefotetan (YM09330) is a semi-synthetic injectable antibiotic which was discovered and developed by Yamanouchi Pharmaceutical Co., Ltd. and has been on the market since 1983. This compound shows a strong and wide spectrum of antibacterial activity and high stability against β-lactamase This paper outlines the optimization of the synthetic process, the replacement of the trifluoroacetic acid used for the cleavage method of benzhydryl ester, work on the stability of diphenyldiazomethane, an alternative synthetic route to Cefotetan, the method for synthesizing the isothiazole derivative and the scale-up of Cefotetan synthesis.