1 0 0 0 OA セフォテタン合成の工程開発と工業化
- 著者
- 藤本 正治
- 出版者
- The Society of Synthetic Organic Chemistry, Japan
- 雑誌
- 有機合成化学協会誌 (ISSN:00379980)
- 巻号頁・発行日
- vol.57, no.5, pp.374-381, 1999-05-01 (Released:2009-11-16)
- 参考文献数
- 9
- 被引用文献数
- 2 3
Cefotetan (YM09330) is a semi-synthetic injectable antibiotic which was discovered and developed by Yamanouchi Pharmaceutical Co., Ltd. and has been on the market since 1983. This compound shows a strong and wide spectrum of antibacterial activity and high stability against β-lactamase This paper outlines the optimization of the synthetic process, the replacement of the trifluoroacetic acid used for the cleavage method of benzhydryl ester, work on the stability of diphenyldiazomethane, an alternative synthetic route to Cefotetan, the method for synthesizing the isothiazole derivative and the scale-up of Cefotetan synthesis.
1 0 0 0 β-ラクタム抗生物質セフォテタンの合成研究
- 著者
- 岩波 勝 前田 哲哉 藤本 正治 長野 嘉信 長野 憲昭 山崎 敦城 柴沼 忠夫 玉沢 一晴 矢野 邦一郎
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.28, no.9, pp.2629-2636, 1980-09-25 (Released:2008-03-31)
- 参考文献数
- 14
- 被引用文献数
- 11 16
A novel intramolecular rearrangement of isothiazolethioacetamides into 1, 3-dithietanecarboxamides is described, together with the synthesis of a new cephamycin derivative (YM-09330) having a 1, 3-dithietane structure at the 7β-position. This compound showed strong antibacterial activity, especially against gram-negative organisms.