Omega-6/Omega-3 Ratio as Major Risk Factor for Atherosclerosis –Lower intake of Linoleic Acid & higher Omega-3, particularly EPA/DHA is necessary in Western countries for effective prevention of atherosclerosis, apoplexy, allergic hyper-reactivity, cancers https://t.co/8hGvYFrFrp

Uric Acid vs Atherosclerotic Plaque Instability –Promoted atherosclerosis & exacerbated plaque vulnerability (increased macrophage infiltration, lipid accumulation, enlarged necrotic cores.. less collagen fibers). More apoptosis & less autophagy in plaques https://t.co/fhoJazBFlI

Mouth breathing (MB) vs memory & learning ability in growing rats – Trial time (maze) to accomplish each task was significantly longer in MB group – Brain: Number of pyramidal cells significantly less in MB rats vs controls in both the CA1 and CA3 regions https://t.co/LPa7Drh6Xl https://t.co/UQJ6jPdXYy

Midlife Intakes of Isoflavone Genistein & Soy vs Risk of Late-life Cognitive Impairment —Compared to lowest quartile of energy-adjusted genistein intake, highest quartile significantly associated with cognitive impairment (OR=1.51; 1.02/2.24; P-trend=0.03) https://t.co/BujsxK1kgg

Fluoride vs Cancer —Cancers of oral cavity, pharynx, colon/rectum, hepato-biliary & urinary organs, brain tumors, T-cell system Hodgkin's disease, Non-Hodgkin lymphoma, multiple myeloma, melanoma, monocytic leukaemia all positively associated with fluoride https://t.co/WcDdGPsLB4

Fluoride in Drinking Water vs Uterine Cancer Mortality —Significant positive correlation in 20 municipalities (r=.626;p<.005). Even after adjusting for confounders association significant —Time trends in mortality seem to be related to fluoridation changes https://t.co/SvrXjq7BCj

Low Cholesterol Associated With Mortality From Stroke, Heart Disease,Cancer —Age-adjusted HR of low cholesterol (<4.14 mmol/L) for mortality HR=1.49 in men & HR=1.50 in women vs moderate level (4.14–5.17) —High cholesterol (≥6.21 mmol/L) not a risk factor https://t.co/HLuoa9HADY

Cadmium Concentration in Chocolate & Cocoa Powder Products in Japan — Cadmium concentrations in chocolate and cocoa powder products on the Japanese market exceeded the European maximum levels for 8/180 chocolate products and 26/140 cocoa powder products. https://t.co/EDwyxhaoHG

Tissue Taurine Depletion Induces Profibrotic Gene Expression & Causes Aging-Related Cardiac Fibrosis in Heart in Mice — Low dietary taurine results in dilated cardiomyopathy in cats, in mice taurine deficiency reduces cardiac function with advancing age https://t.co/VuTjre2Gyq

Carnosine vs Brain Ischemia (rats) — Mortality after ischemic attack decreased (from 55% to 17%) & most of the learning parameters kept at the pre-ischemic level. Monoamine oxidase B activity in brain of carnosine treated rats was not changed by ischemia. https://t.co/CNNn96aeIv

Low Carnitine Causes Death from Hypoglycemia — For normal mice survival rate 100%, no hypoglycemia at all — For carnitine deficiency mice, survival rate 77% on day 14; 28% on day 28. From day 21 on, hypoglycemia seen — Gastric lactose disappeared by day 17 https://t.co/MIwojYiUQh

Triglycerides vs Cardiovascular Disease Mortality (20-year Follow-up) — Compared with a non-fasting TG of 150–179 mg/dL, non-fasting TG ≥210 mg/dL significantly associated with increased risk for CVD mortality (HR=1.56; 1.01/2.41) https://t.co/dQ7K9wQEvX

Uric Acid vs Coronary Plaque Characteristics on Optical Coherence Tomography — The relationship between high-sUA levels and typical vulnerable features of plaques persisted after balancing the traditional risk factors. https://t.co/NKF7JP2GFD

Inhibitory Effects of Vitamin A and Its Derivatives on Cancer Cell Growth Not Mediated by Retinoic Acid Receptors — Lessons learned from these findings: nutritional management of vitamin A leads to prevention and treatment of cancer... https://t.co/h2qgBjeYSK

Milk/Meat/Fish vs Cerebrovascular Disease Mortality (leading cause of death from 1955 to 1980 in Japan) — Findings suggest that the increasing intake of animal fat and/or protein may have played a key role in reducing cerebrovascular disease in Japan https://t.co/W4reMtUf42

Magnesium vs Mortality — Patients with serum Mg ≤2.3 mg/dL constituted the low Mg group. All-cause mortality was significantly higher in the low Mg group HR=1.72; (1.14/2.58; p<0.01) — Association particularly strong in males HR=2.08 (1.19/3.63; p<0.05) https://t.co/q4bHCjahqt

Exercise Habits vs Mortality (General Japanese Population; 20-Year Follow-Up; n=7,709) — Mortality 12% higher in non-exercisers vs exercisers (1%-24%), — Mortality from heart failure 68% higher in non-exercisers than in exercises (3%-173%) https://t.co/pFaXI5HmUd

Wakeup Frequency at Night vs Atherogenic Dyslipidemia — A wakeup frequency ≥ 3 times/night independently associated with an increased risk OR=1.96 (1.17/3.28), and non-HDL-C ≥ 160 mg/dL was OR=1.78 (1.09/2.89), particularly in women https://t.co/ZZKo1nGX9u

Low LDL-Cholesterol bad for you, like always Triglycerides vs Ischemic Cardiovascular Diseases (n=6,684 follow-up 15y) — For decile-10 of TG: HR=1.56 (1.05–2.32) — For each SD of TG: HR=1.30 (1.00–1.70) in LDL-C ＜140 mg/dL HR=1.07 (0.77–1.50) in LDL≥140 https://t.co/PmXyQl1sZ8

Fasting blood glucose in middle age vs cognitive function in later life — Cognitive impairment: MoCA-J score ≤25 — Odds ratio of MoCA-J ≤25 in Diabetes OR=3.29 — Multivariable-adjusted MoCA-J scores 25.2 normal 24.8 impaired fasting glucose 23.4 Diabetes https://t.co/5S1YHo3rKT

Triglycerides vs atherosclerosis (Carotid Stenosis Progression CSP) —Non-fasting TG an independent risk factor of CSP —Cutoff value of non-fasting TG to discriminate CSP 169.5 mg/dL for carotid arteries with baseline stenosis of <50% & 154.5mg/dL for ≥50% https://t.co/b9SWRl9UPc

Gut microbiome of elderly women born in Japanese longevity village Ogimi — No differences in alpha/beta diversity; however the elderly women who lived in Ogimi during first 3 years of their lives had higher rate of (mucin-degrading) Akkermansia muciniphila https://t.co/FFaiRWdP1r

Non-fasting triglycerides vs CVD mortality (n=6,831 follow-up 20y) — Compared with nonfasting TG of 150-179 mg/dL, TG ≥210 mg/dL➡️CVD mortality HR=1.56 (1.01-2.41) — Lower non-fasting TG also significantly associated with increased risk for fatal #CVD https://t.co/dQ7K9wQ6Gp https://t.co/jmBOHnQtTp

Fasting reshapes fat tissue — Dramatically upregulated Sirt5 expression levels & fat tissue succinylation — Increased M2- polarization of macrophages in WAT white fat tissue of HFD-fed mice — Promoted beiging of white adipose tissue in both LFD- & HFD-fed https://t.co/hnubveAMvY

Chloroquine phosphatee, old malaria drug, shows efficacy in treatment of #coronavirus pneumonia in clinical studies... antiviral by ⬆️endosomal pH required for virus/cell fusion & interfering with glycosylation of cellular receptors of #COVID19. https://t.co/7fq7dogZbd #2019nCoV

J-STAGE Articles - IgG4-related Disease Emerging after COVID-19 mRNA Vaccination: A Case Report https://t.co/KYxq3G4ZWA Not surprised. https://t.co/cCR87g0dNq

Uric Acid vs Atherosclerotic Plaque Instability –Promoted atherosclerosis & exacerbated plaque vulnerability (increased macrophage infiltration, lipid accumulation, enlarged necrotic cores.. less collagen fibers). More apoptosis & less autophagy in plaques https://t.co/fhoJazBFlI