著者

今村 孝史 野田 敦子 柴田 重信 渡辺 繁紀 野田 浩司 小野 容子 後藤 茂 井上 善文

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.113, no.5, pp.400-405, 1993-05-25

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A series of pentanthrene type heterocyclic compounds were synthesized and evaluated for anxiolytic activities by three kinds of behavioral pharmacological tests. Several compounds showed anxiolytic activities. In particular, s-triazolo [3,4-a] phthalazine (Tri-P) and 3-propyl derivatives of Tri-P (PTP) showed remarkable activities, although the activities were slightly lower than those of diazepam. The results suggested that Tri-P or PTP is a useful lead compound for the development of the antianxietic agents. The relationship between the structure and anxiolytic activity, and the inducing mechanism of the activity was discussed.