1 0 0 0 OA ペントアンスレン型構造を有する複素環化合物のモノアミン酸化酵素阻害活性
- 著者
- 野田 敦子 野田 浩司 今村 孝史 小野 行雄 森田 美華 甲斐 麻美子 嶺 佐知子 後藤 茂
- 出版者
- 公益社団法人 日本薬学会
- 雑誌
- YAKUGAKU ZASSHI (ISSN:00316903)
- 巻号頁・発行日
- vol.111, no.9, pp.499-503, 1991-09-25 (Released:2008-05-30)
- 参考文献数
- 16
- 被引用文献数
- 3 6
Pentanthrene type heterocyclic compounds, which contain oxazole, isoxazole, oxadiazole, thiazole, isothiazole, thiadiazole or pyrrole ring as C-ring, and naphthalene, quinoline, isoquinoline or quinoxaline ring as A·B-ring, were prepared, and their monoamine oxidase (MAO) inhibitory activities were examined. As expected from our previous investigation on the structure-activity relationship of this series, most of them showed strong inhibitory potency to both MAO-A and MAO-B. However, a few indicated highly selective inhibition for either of MAO subtypes.
1 0 0 0 OA ペントアンスレン型複素環化合物の抗不安作用
- 著者
- 今村 孝史 野田 敦子 柴田 重信 渡辺 繁紀 野田 浩司 小野 容子 後藤 茂 井上 善文
- 出版者
- 公益社団法人日本薬学会
- 雑誌
- 藥學雜誌 (ISSN:00316903)
- 巻号頁・発行日
- vol.113, no.5, pp.400-405, 1993-05-25
A series of pentanthrene type heterocyclic compounds were synthesized and evaluated for anxiolytic activities by three kinds of behavioral pharmacological tests. Several compounds showed anxiolytic activities. In particular, s-triazolo [3,4-a] phthalazine (Tri-P) and 3-propyl derivatives of Tri-P (PTP) showed remarkable activities, although the activities were slightly lower than those of diazepam. The results suggested that Tri-P or PTP is a useful lead compound for the development of the antianxietic agents. The relationship between the structure and anxiolytic activity, and the inducing mechanism of the activity was discussed.