著者

奥山 徹 高田 光正 柴田 承二 保尊 正幸 川田 忠典 正木 久朗 野口 輝彦

出版者

日本生薬学会

雑誌

生薬学雑誌 (ISSN:00374377)

巻号頁・発行日

vol.41, no.2, pp.p147-152, 1987-06

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Some Chinese herbal prescriptions employed for a syndrome expressed in oriental medical concept as chest paralysis (Kyohi) and heartache (Shintsu) are thought to be effective for angina pectoris. We investigated the effects of 5 Chinese medicinal prescriptions, Kuolon-Xiebai-Banxia Tang (Karo-gaihaku-hange-to), Guizhi-Shenjiang-Zhishi Tang (Keishi-shokyc-kijitsu-to), Jupi-Zhishi-Shenjiang Tang (Kippi-kijitsu-shokyo-to), Renshen Tang (Ninjin-to) and Guizhi-Renshen Tang (Keishi-ninjin-to) and 6 individual herbs contained in these prescriptions on a human platelet aggregation induced by 2 μM ADP. All the prescriptions mentioned above showed a strong inhibitory effect in the secondary wave aggregation, while Jupi-Zhishi-Shenjiang Tang and Guizhi-Renshen Tang gave less effect in the primary wave aggregation. Of these herbs, Shenjiang (Zingiberis Rhizoma), Ganjiang (Zingiberis Siccatum Rhizoma) and Renshen (Ginseng Radix) showed a strong inhibitory effect, while Jupi (Aurantii Nobilis Pericarpium) promoted the primary wave aggregation. Gancao (Glycyrrhizae Radix) and Baizhu (Atractyloides Rhizoma) showed no activity.