著者

小竹 要 大江 国広 長谷田 恭子 吉野 公明 万見 新太郎 黒田 満彦 松田 保 竹田 亮祐 村上 元孝

出版者

一般社団法人 日本血液学会

雑誌

臨床血液 (ISSN:04851439)

巻号頁・発行日

vol.15, no.5, pp.487-494, 1974

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Studies on platelet functions of 21 patients with renal insufficiency have been preformed. Platelet counts were significantly decreased in uremic patients, although severe thrombocytopenia less than 100&times;10³ platelets/mm³ was detected only in two patients. Platelet adhesiveness to glass was remarkably decreased in uremic patients. Platelet factor-3 availability was impaired in some of these patients, while platelet factor-3 activity was not decreased. Clot retraction was slightly defective in few patients. The significant correlation was not found between platelet adhesiveness and BUN, creatinine, uric acid or inorganic phosphate level in the serum of these patients. The abnormalities of platelet functions were partially corrected after dialysis.<br>In vitro, urea at high concentration showed an inhibitory effect on platelet aggregation. Guanidinosuccinic acid had less inhibitory effect on platelet aggregation, and creatinine had no inhibitory effect.