1 0 0 0 OA グルタチオンのメラニン合成阻害機構
- 著者
- 松木 光雄 渡部 俊彦 小笠原 綾子 三上 健 松本 達二
- 出版者
- 公益社団法人 日本薬学会
- 雑誌
- YAKUGAKU ZASSHI (ISSN:00316903)
- 巻号頁・発行日
- vol.128, no.8, pp.1203-1207, 2008 (Released:2008-08-01)
- 参考文献数
- 10
- 被引用文献数
- 12 17
Glutathione dose dependently inhibited melanin synthesis in the reaction of tyrosinase and L-DOPA. The inhibition of melanin synthesis was recovered by increasing the concentration of L-DOPA, but not recovered by increasing tyrosinase. Glutathione inhibited the binding between tyrosinase and L-DOPA. Although the synthesized melanin was aggregated within 1 h, the aggregation was inhibited by the addition of glutathione. These results indicate that glutathione inhibits the synthesis and agglutination of melanin by interrupting the function of L-DOPA.
