著者

三輪 宜一

出版者

一般社団法人 日本臨床薬理学会

雑誌

臨床薬理 (ISSN:03881601)

巻号頁・発行日

vol.39, no.5, pp.157-161, 2008 (Released:2009-02-05)

参考文献数

18

著者

三輪 宜一 田場 洋二 宮城 めぐみ 笹栗 俊之

出版者

公益社団法人 日本薬理学会

雑誌

日本薬理学雑誌 (ISSN:00155691)

巻号頁・発行日

vol.123, no.1, pp.34-40, 2004 (Released:2003-12-23)

参考文献数

27

被引用文献数

4 4

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プロスタグランジンJ2(PGJ2),Δ12-PGJ2,15-デオキシ-Δ12,14-PGJ2(15d-PGJ2)の三者を含むPGJ2ファミリーは,生体内ではアラキドン酸代謝の過程においてPGD2が非酵素的に変換され生成される.これらPGJ2ファミリーの薬理作用としては,古くからがん細胞やウイルスの増殖を強力に抑制することが知られていた.しかしながらその他の作用についてはほとんど知られていなかった.その後,1995年にPGJ2ファミリーが脂肪細胞の分化に必要な核内受容体peroxisome proliferator-activated receptor γ(PPARγ)のリガンドであることが明らかになって以来,研究が飛躍的に進んだ.特に15d-PGJ2は現在のところ最も強力な内因性PPARγリガンドとして知られており,抗炎症作用,アポトーシス抑制および誘導作用,分化誘導作用等の新たな薬理作用を有することが見出された.本稿では主に心血管系の細胞を中心に,これまでに明らかにされたPGJ2ファミリーの薬理作用およびその機序についてまとめた.

著者

三輪 宜一

出版者

一般社団法人 日本臨床薬理学会

雑誌

臨床薬理 (ISSN:03881601)

巻号頁・発行日

vol.52, no.3, pp.89-93, 2021

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<p>In recent years, many excellent drugs with few side effects have been introduced into treatment and contribute to improving prognosis, but elderly people often have multiple diseases and take many drugs in combination. As a result, the existence of drug interactions has become more important as a risk factor for the occurrence of adverse drug reactions(ADRs). In Japan as well, the importance of drug interactions has been recognized since the Sorivudine incident in 1993, in which sorivudine, a therapeutic drug for herpes zoster, caused death due to serious myelosuppressive side effects when used in combination with 5-FU anticancer drugs, and cautions have been issued such as the revision of the description procedure in the package insert. In addition, efforts are being made by various parties concerned in the drug development process. In 2018, the Ministry of Health, Labor and Welfare issued the “Guideline on drug interaction for drug development and appropriate provision of information” regarding the method of examining drug interactions and the provision of information.</p><p>On the other hand, looking at the medical field, although some side effects of individual drugs and interactions between the two drugs are described in the package insert, it is impossible to grasp all of them. In addition, even if the drug therapy is recommended in the treatment guidelines for a certain disease, if the drug is complicated with another disease, the drug interaction with the recommended drug for those diseases may become a problem. A meta-analysis of prospective studies on the incidence of drug-induced ADRs in inpatients published by the United States in 1998 estimated that 106,000 people die annually from ADRs. Healthcare professionals are required to work harder than ever to prevent ADRs. Even now, medications are checked by pharmacists, but it is hard to say that they are fully prepared for drug interactions.</p><p>In this session, I would like to describe what can be done and what kind of knowledge should be learned to prevent serious drug interactions. Based on that, I would like to think about what points should be emphasized and dealt with in the actual medical field.</p>