著者

上敷領 淳 竹谷 翔太 江本 基樹 杉原 成美

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.40, no.10, pp.609-617, 2014-10-10 (Released:2015-10-10)

参考文献数

30

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The purpose of this study was to investigate the influence of cigarette smoking on the risk of illegal drug abuse and self-medication, such as the proper use of pharmaceutical products, among high school students.An anonymous, self-administered survey was conducted before and after a lecture on the prevention of drug abuse in a high school located in eastern Hiroshima Prefecture in November 2011. The subjects were classified into three groups according to smoking behavior; non-smokers, former smokers, and current smokers. Significant differences were observed between groups.The rate of recognizing health damage caused by the abuse of stimulant drugs, narcotic drugs or solvents was significantly decreased in the cigarette smoking group. In addition, the rate of intent to use drugs that were considered to be “medications that enable them to stay up all night for days”, “medications that would allow them complete recovery from fatigue” or “medications that would improve their appearance” was significantly increased in the cigarette smoking group. The rate of prescription medication compliance, such as confirming their correct usage or following their prescribed usage was significantly decreased in the cigarette smoking group.An influence against illegal drugs and the awareness of the risks of self-medication were observed in non- and former smokers according to the questionnaire performed after the lecture, but the influence on the cigarette smoking group was minimal. Education promoting medication compliance may be necessary for high school students, especially students who abuse cigarettes.

著者

上敷領 淳 西谷 沙織 村上 仁友美 妹尾 典子 筒井 洋望 山崎 迪子 服部 聖 古屋 憲次 杉原 成美

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.40, no.1, pp.54-61, 2014-01-10 (Released:2015-01-10)

参考文献数

27

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Octreotide is often administered to patients by addition to total parenteral nutrition (TPN) as well as by subcutaneous injection. However, the concentration has not been determined to remain greater than 90% through the completion of its administration. This study investigated the stability of octreotide during administration in ELNEOPA No 1 TPN solution, a four-chambered duplex delivery system.The level of octreotide in the upper-chamber of the ELNEOPA No 1 duplex delivery system, pH 4.0, remained stable, whereas that in the lower chamber, pH 7.0, decreased to less than 90% of the initial concentration immediately after mixing. The final concentration of octreotide in pH 7.5 buffer solution was significantly lower than that in pH 5.1 buffer solution. The influence of pH was reversible. However, a fraction of octreotide suffered decomposition in pH 7.5 buffer solution. Hence, it might be suitable to inject octreotide into the upper chamber that has the lowest pH among the 4 chambers of the duplex drug delivery system used by ELNEOPA No 1.Reducing agents such as sodium hydrogen sulfite caused the concentration of octreotide to decrease. Although the mixed solution of the 4 chambers contains sodium hydrogen sulfite, the concentration of octreotide remained greater than 90% for about 3 days. The decrease in concentration caused by sodium hydrogen sulfite seemed to be protected by the co-presence of glucose or cysteine.The results of our octreotide concentration studies suggest the possibility that the therapeutic effects of octreotide administered via TPN would be equivalent to the effects following subcutaneous administration.