著者

上敷領 淳 竹谷 翔太 江本 基樹 杉原 成美

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.40, no.10, pp.609-617, 2014-10-10 (Released:2015-10-10)

参考文献数

30

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The purpose of this study was to investigate the influence of cigarette smoking on the risk of illegal drug abuse and self-medication, such as the proper use of pharmaceutical products, among high school students.An anonymous, self-administered survey was conducted before and after a lecture on the prevention of drug abuse in a high school located in eastern Hiroshima Prefecture in November 2011. The subjects were classified into three groups according to smoking behavior; non-smokers, former smokers, and current smokers. Significant differences were observed between groups.The rate of recognizing health damage caused by the abuse of stimulant drugs, narcotic drugs or solvents was significantly decreased in the cigarette smoking group. In addition, the rate of intent to use drugs that were considered to be “medications that enable them to stay up all night for days”, “medications that would allow them complete recovery from fatigue” or “medications that would improve their appearance” was significantly increased in the cigarette smoking group. The rate of prescription medication compliance, such as confirming their correct usage or following their prescribed usage was significantly decreased in the cigarette smoking group.An influence against illegal drugs and the awareness of the risks of self-medication were observed in non- and former smokers according to the questionnaire performed after the lecture, but the influence on the cigarette smoking group was minimal. Education promoting medication compliance may be necessary for high school students, especially students who abuse cigarettes.

著者

横田 いつ子 鶴崎 健一 杉原 成美

出版者

福山大学薬学部

雑誌

福山大学薬学部研究年報 = Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University (ISSN:0288724X)

巻号頁・発行日

no.27, pp.39, 2009-12-25

著者

杉原 成美 岩井 美織 橘高 美和子 瀬尾 誠 岡田 昌浩 金子 三屋子 横田 いつ子

出版者

日本社会薬学会

雑誌

社会薬学 (ISSN:09110585)

巻号頁・発行日

vol.37, no.2, pp.147-155, 2018-12-10 (Released:2019-01-19)

参考文献数

33

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The questionnaire was distributed to caregivers regarding their management for home medication therapy. The purpose of this questionnaire was to clarify the role of community pharmacists in city “Z”, Hiroshima in supporting this activity. The results were compared among seven administrative zones. The percentage of caregivers who had routinely administered medications to dependent patients was 81%. Of these, the percentage of caregivers who had encountered difficulty in medication administration to dependent patients was 66%. Only 13% of these caregivers had sought assistance from pharmacists in dealing with issues they faced in the administration of medications. The percentage of caregivers who had easy access to pharmacists was 44%. The percentage of caregivers who received pharmacist-initiated information about patients was 23%. Among the 7 administrative zones in city “Z”, the 2 zones (H-zones) with the highest percentage of elderly citizens, 38.7%, were compared with the other 2 zones (L-zones) with the lowest percentage of elderly citizens, 25.7%, regarding medication management by caregivers. It was observed that the frequency of missing side effects or crushing medicines by caregivers was higher in H-zones as compared to L-zones. The results of this research suggest that close cooperation between pharmacists and caregivers improves the quality of medication therapy management. In an aging society, pharmacist intervention could be very beneficial to providing support and information that would improve the quality of patients’ medication therapy.

著者

上敷領 淳 西谷 沙織 村上 仁友美 妹尾 典子 筒井 洋望 山崎 迪子 服部 聖 古屋 憲次 杉原 成美

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.40, no.1, pp.54-61, 2014-01-10 (Released:2015-01-10)

参考文献数

27

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Octreotide is often administered to patients by addition to total parenteral nutrition (TPN) as well as by subcutaneous injection. However, the concentration has not been determined to remain greater than 90% through the completion of its administration. This study investigated the stability of octreotide during administration in ELNEOPA No 1 TPN solution, a four-chambered duplex delivery system.The level of octreotide in the upper-chamber of the ELNEOPA No 1 duplex delivery system, pH 4.0, remained stable, whereas that in the lower chamber, pH 7.0, decreased to less than 90% of the initial concentration immediately after mixing. The final concentration of octreotide in pH 7.5 buffer solution was significantly lower than that in pH 5.1 buffer solution. The influence of pH was reversible. However, a fraction of octreotide suffered decomposition in pH 7.5 buffer solution. Hence, it might be suitable to inject octreotide into the upper chamber that has the lowest pH among the 4 chambers of the duplex drug delivery system used by ELNEOPA No 1.Reducing agents such as sodium hydrogen sulfite caused the concentration of octreotide to decrease. Although the mixed solution of the 4 chambers contains sodium hydrogen sulfite, the concentration of octreotide remained greater than 90% for about 3 days. The decrease in concentration caused by sodium hydrogen sulfite seemed to be protected by the co-presence of glucose or cysteine.The results of our octreotide concentration studies suggest the possibility that the therapeutic effects of octreotide administered via TPN would be equivalent to the effects following subcutaneous administration.