著者

中山 惠利子

雑誌

阪南論集.人文自然科学編

巻号頁・発行日

vol.56, no.1, pp.1-17, 2020-10

著者

中山 惠太 白川 真一 矢田 紀子 長尾 智晴

出版者

進化計算学会

雑誌

進化計算学会論文誌 (ISSN:21857385)

巻号頁・発行日

vol.3, no.2, pp.12-21, 2012 (Released:2012-06-11)

参考文献数

12

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Non-photorealistic rendering (NPR), a research about non-photorealistic images is a major field of research in image processing. Painterly rendering is a method that creates artistic images based on photo images and important in NPR. Recently, painterly rendering methods using evolutionary algorithm are studied. Those studies have intended to optimize the process of creating artistic images by using evolutionary algorithm. Most of those studies have focused on generating and placing strokes as a painting operation. On the other hand, some researchers proposed painterly rendering methods using existing art images. They have created painting images which have unique colors and textures of existing art images, called “painting style”. We propose a new method to create artistic images based on photo images and existing art images by using Genetic Algorithm (GA). Our method operates putting the “patches” on a canvas image repeatedly as a painting operation. We generate the “patches” by copying a part of the existing art images and put them on the canvas image in mutation of GA. We exchange pixels in the same region of two canvas images in crossover of GA. In the process of optimization, our method brings the canvas image close to the photo images. Our method evolutionarily creates the painting images which have the painting styles of existing art images.

著者

小林 大介 久津間 信明 中山 惠 鵜近 篤史 鈴木 暢之 佐次田 優子 遠藤 敏成 上田 秀雄 沼尻 幸彦 駒田 富佐夫 齋藤 侑也 森本 雍憲

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.6, pp.571-575, 2002-12-10 (Released:2011-03-04)

参考文献数

10

被引用文献数

2 1

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When a novel additional adverse effect is reported for a marketed medicine, the medical information leaflet has to be revised to inform physicians and pharmacists of this. Pharmacists are responsible for informing patients of early warning symptoms to avoid the subsequent appearance of severe adverse effects. However, at present, patients may suffer from severe adverse events because such symptoms may remain unrecognized until the medicine is on the market. As a result, investigations to predict and prevent novel additional adverse effects of medicines are required. In this study, we investigated a novel additional adverse effect classified as a pharmacological effect based on the drug safety update (DSU). As a result, skin disorders including toxic epidermal necrolysis and Stevens Johnson syndrome, and pseudomembranous colitis have become evident as additional adverse effects of antibiotics, with a high incidence. In addition, neuroleptic malignant syndrome and aplastic anemia have also been reported as adverse effects of central nervous system agents.Therefore, it is important to provide patients with information about the early warning symptoms related to such adverse effects, even though such adverse effects are not contained in the patient information leaflet.