1 0 0 0 OA 協働研究所による産学連携NEDOプロジェクトの成果
- 著者
- 中澤 慶久 武野 真也 鈴木 伸昭 後藤 芳一
- 出版者
- 研究・イノベーション学会
- 雑誌
- 年次学術大会講演要旨集
- 巻号頁・発行日
- vol.32, pp.864-865, 2017-10-28
一般講演要旨
1 0 0 0 OA 杜仲葉エキスの血圧降下に関する研究(第2報)
- 著者
- 田川 智恵 中澤 慶久 田頭 栄治郎 上田 太郎 山口 康代 大原 豊実 鬼塚 重則 西部 三省
- 出版者
- 日本生薬学会
- 雑誌
- 生薬學雜誌 (ISSN:13403443)
- 巻号頁・発行日
- vol.59, no.3, pp.117-120, 2005-06-20
In order to clarify the mechanism of the antihypertensive effect of Eucommia leaf (Eucommia ulmoides Oliver) extract (ELE), ELE was partitioned into two fractions, water eluted fraction (H_2O ext.) and methanol eluted fraction (MeOH ext.)(Eueommia leaf glycoside), by using a Diaion HP-20 column. The antihypertensive effects of ELE and two fractions were investigated by their intravenous (i.v.) administration to SHR. Transient antihypertensive effects were shown in ELE and MeOH ext. and their effects were respectively attenuated by i.v. injection of atropine, suggesting that the antihypertensive effects of both ELE and MeOH ext. might be mediated via the muscarinic acetylcholine receptors. On the other hand, H_2O ext. showed the sustained antihypertensive effect which was not attenuated by i.v. injection of atropine. This result suggested that two types of components which have different mechanisms of antihypertensive effect are contained in ELE.