著者

島 由樹 河相 安彦 郡司 敦子 遠藤 弘康 久山 佳代 山本 浩嗣

出版者

Japanese Society of Oral Medicine

雑誌

日本口腔粘膜学会雑誌 (ISSN:13417983)

巻号頁・発行日

vol.13, no.2, pp.68-73, 2007-12-30 (Released:2010-02-25)

参考文献数

30

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本報告では, 自傷行為によって生じた歯肉外傷の1例を示す。症例は54歳女性であり, 統合失調症と診断されている。唇側付着歯肉に限局した複数の潰瘍形成が認められた。他の口腔粘膜に病変は認めなかった。問診により過度なブラッシングが確認されたことから, 本症例は歯ブラシの誤用が原因で生じた歯肉外傷と診断された。患者には適切な口腔衛生指導を行い, 1週間後には歯肉症状の寛解が認められた。

著者

岩井 恵理華 山本 泰 飯塚 普子 末光 正昌 久山 佳代 小宮 正道

出版者

公益社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.67, no.11, pp.630-633, 2021-11-20 (Released:2022-01-20)

参考文献数

12

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Dipeptidyl peptidase-4 (hereinafter referred to as DPP-4) inhibitors are used in diabetes therapy. They lower blood glucose by inhibiting DPP-4 and promoting insulin secretion. Here, we report a case of oral mucous membrane pemphigoid caused by the oral administration of a DPP-4 inhibitor. A 61-year-old female with gingival erosion and bleeding in the maxilla from the right first premolar to the left first premolar was referred to our department. On the first visit, redness, blisters, erosion, and the Nikolsky phenomenon were observed in the aforementioned region. A biopsy was performed for suspected pemphigoid. A histopathologicaldiagnosis of pemphigoid was obtained using HE staining and the fluorescent antibody method. The patient had diabetes and had been taking a combination drug containing vildagliptin (DPP-4 inhibitor) and metformin hydrochloride for two years and six months. We suspected that the pemphigoid was caused by the DPP-4 inhibitor. A request for a prescription modification was made to the internal medicine department, and the DPP-4 inhibitor was replaced with canagliflozin hydrate. The symptoms (redness, blisters, erosion, and the Nikolsky phenomenon) disappeared one month after suspension of the drug containing the DPP-4 inhibitor. Furthermore, relapse has not occurred in the 2 years since.