著者
矢島 優己 藤盛 真樹 嶋崎 康相 佐藤 栄晃 吉田 将亜 竹川 政範
出版者
公益社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.66, no.11, pp.565-571, 2020-11-20 (Released:2021-01-20)
参考文献数
15

Calcium hydroxide formulation is frequently used in the treatment of root canals. We report a case where this formulation caused maxillary vascular embolism. A patient received an injection of calcium hydroxide formulation in to the right maxillary lateral incisor in a dental clinic. Immediately after, he presented with swelling of the surrounding gingiva, right cheek swelling, pain, and malaise. Necrosis of the right palate mucosa was observed. A CT image showed calcium hydroxide formulation confirmed to running from the greater palatal artery to the maxillary artery. We diagnosed maxillary vascular embolism caused by calcium hydroxide. On day 32, necrotic tissue of the palate mucosa was removed as much as possible under local anesthesia. On Day 233, the right upper 2 teeth were extracted and a radicular cyst was removed. On day 335, the redness on the right cheek skin almost disappeared, and the opening increased to 42 mm. The right oral and extraoral hypoesthesia remained, but was improving, and the right palate mucosa was completely epithelialized.
著者
中嶋 正博
出版者
公益社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.58, no.8, pp.473-479, 2012-08-20 (Released:2014-11-14)
参考文献数
9
被引用文献数
1 4

Othognathic surgery for jaw deformities are most frequently performed in Japan. Regarding those procedures, Le Fort I osteotomy and anterior maxillary alveolar osteotomy in the maxilla, and sagittal split ramus osteotomy, intraoral vertical ramus osteotomy, anterior mandibular alveolar osteotomy, and genioplasty in the mandibule are selected singly or combined based on cases. Among these orthgnathic surgeries, Le Fort I osteotomy is a typical surgical procedure, as well as sagittal split ramus osteotomy. Although the designing of osteotomy lines in Le Fort I osteotomy is simple, this surgical procedure is apt to be regarded as difficult, due to other risk factors in comparison with mandibular osteotomy, such as difficulty in the repositioning of bone segment, complexity of the maxillary bone structure, bleeding, surgical invasion of the nasal cavity and paranasal sinus, and postoperative changes in the nasal base morphology. However, regarding surgical treatment for jaw deformities, Le Fort I osteotomy is considered to be a surgical procedure which we should master, as well as sagittal split ramus osteotomy.Basically, orthognathic surgeries involve subperiosteal surgical manipulation, and it is simply summarized that Le Fort I osteotomy should also be carefully performed without injuring the periosteum. In order to achieve this, it is necessary to accumulate experience, sufficiently understanding the basic factors to safely perform Le Fort I osteotomy. This manuscript outlines the major points in the surgical procedure of Le Fort I osteotomy.
著者
藤盛 真樹 鳥谷部 純行 角 伸博 嶋﨑 康相 宮澤 政義 宮手 浩樹 北田 秀昭 佐藤 雄治 三澤 肇 山下 徹郎 中嶋 頼俊 針谷 靖史 小林 一三 西方 聡 太子 芳仁 杉浦 千尋 笠原 和恵 浅香 雄一郎 榊原 典幸 岡田 益彦 柴山 尚大 末次 博 鈴木 豊典 阿部 貴洋 谷村 晶広 工藤 章裕 道念 正樹 川口 泰 野島 正寛 牧野 修治郎
出版者
公益社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.68, no.4, pp.168-183, 2022-04-20 (Released:2022-06-20)
参考文献数
38

Tooth extraction is reported as the main trigger of bisphosphonate (BP) -related osteonecrosis of the jaw (BRONJ). A method to prevent BRONJ has not been scientifically proven. The American Association of Oral and Maxillofacial Surgeons (AAOMS) differs from the International Task Force on Osteonecrosis of the Jaw with regard to the prevention of BRONJ via prophylactic withdrawal before tooth extraction. We performed a multicenter prospective study regarding the development of BRONJ after tooth extraction in BP-treated patients for the purpose of determining factors associated with the frequency of BRONJ. We extracted teeth from patients with a history of current or prior treatment with BP preparations; teeth were extracted using a common treatment protocol. The presence or absence of BRONJ and adverse events were evaluated. A total of 1,323 cases were targeted for this study; 2,371 teeth were extracted. The overall incidence of BRONJ was 1.74%; in the prophylactic withdrawal group it was 1.73%, whereas in the prophylactic non-withdrawal group it was 1.75%. Factors associated with the onset of BRONJ were sex, preparation adaptation classification, oral hygiene state, site of tooth extraction, and Denosumab usage. From analysis that considered the effect of confounding using the propensity score, prophylactic BP withdrawal did not result in a reduction of BRONJ (onset odds ratio with withdrawal: 1.13, 95%CI 0.36-3.57).
著者
梅田 正博
出版者
公益社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.66, no.2, pp.52-60, 2020-02-20 (Released:2020-04-20)
参考文献数
21
被引用文献数
1

We describe the treatment and prevention methods for medication-related osteonecrosis of the jaw (MRONJ) based on the results of multicenter clinical trials conducted by the authors. The standard treatment for MRONJ is surgery. It is thought that conservative treatment precedes and surgical treatment is performed only in non-healing cases, but conservative treatment not only has a significantly lower cure rate, but there are also cases where the range of necrotic bone rapidly expands during conservative treatment. Therefore, in the case of operable cases, it is better to use early surgical treatment as the first choice treatment. Drug holiday of antiresorptive agents prior to MRONJ surgery does not improve the cure rate and therefor is not necessary. In addition, treatment results do not be improved even if antibiotics were given before surgery. In MRONJ surgery, it is most important to completely remove the osteolytic lesion on CT image. In patients showing periosteal reaction, the healing rate decreases. The periosteal reaction site should be included in the resected area, but if the necrotic bone in the bone is completely removed, healing may be obtained even if the periosteal reaction site is left. In order to prevent the onset of MRONJ, tooth extraction should be performed early if there is an infection source tooth, instead of avoiding invasive dental treatment, Drug holiday of antiresorptive agent before tooth extraction does not reduce the incidence of MRONJ.
著者
市山 友子 渡邊 正章 成相 義樹 関根 浄治
出版者
公益社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.61, no.3, pp.182-186, 2015-03-20 (Released:2015-09-29)
参考文献数
17

Trigeminocardiac reflex (TCR) occurs rarely during oral and maxillofacial surgery. We report a case of sinus arrest caused by TCR during extraction of an impacted lower third molar in a 41-year-old woman referred to our department for tooth extraction. The preoperative electrocardiogram showed normal sinus rhythm. When the surgeon started luxation of the left impacted lower third molar with the patient under intravenous sedation with propofol, sinus arrest suddenly occurred. The surgery and propofol administration were discontinued immediately. The period of sinus arrest was 20 seconds, after which heart rate recovered to 70 beats per minute. The operation was resumed with the patient under propofol sedation, and no further sinus arrest occurred. It is likely that sinus arrest in this patient was caused by mechanical pressure on the inferior alveolar nerve. To prevent TCR, it is important to avoid invasive procedures and to use an appropriate local anesthetic during oral and maxillofacial surgery.
著者
泉 喜和子 下田 恒久 下田 哲也 香川 豊宏 池邉 哲郎 大関 悟
出版者
公益社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.56, no.4, pp.261-265, 2010-04-20 (Released:2013-10-19)
参考文献数
13
被引用文献数
2 2

This report describes the feasibility of posterior-superior repositioning of the maxilla by Le Fort Ⅰ osteotomy with a pterygoid process fracture, while preserving the descending palatine artery. We examined movement accuracy and stability in 3 patients in whom maxillary protrusion with vertical maxillary excess was treated by moving the maxilla backward more than 4 mm. The postsurgical positions of the maxilla were more posterior than the presurgical expectations, but the differences were within 1 mm. Cephalometric analysis revealed that the differences in each measurement between immediately and one year after surgery were within 1 degree. Without mandibular osteotomy, maxillary protrusion can be satisfactorily treated with Le Fort Ⅰ osteotomy alone.
著者
田中 宏和 宮澤 英樹 林 清永 峯村 俊一 倉科 憲治 栗田 浩
出版者
公益社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.60, no.10, pp.581-586, 2014-10-20 (Released:2015-07-17)
参考文献数
22
被引用文献数
1 2

The number of patients attacked by bears has been rising recently because the opportunity to encounter wild bears has increased. Bear attacks usually focus on the head and neck areas, and the attack sometimes causes fatal injuries.We report two cases of multiple facial lacerations and mandibular bone comminuted fractures caused by a bear attack.A 70-year-old man and a 60-year-old man were attacked by a black bear while mushroom picking. They sustained mandibular bone comminuted fractures with deep lacerations of the face. They were brought to our emergency room. Their lives were saved by immediate surgery. In addition, it was necessary to provide preventative measures against infection.
著者
梯 裕恵 白石 剛士 河井 洋祐 南里 篤太郎 野田 さわこ 池田 久住 朝比奈 泉
出版者
公益社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.60, no.12, pp.672-676, 2014-12-20 (Released:2015-08-25)
参考文献数
18
被引用文献数
2 4

Mucous-retention cysts such as mucocele and ranula are caused by mucus extravasation due to rupture of ducts of the major and minor salivary glands. While several techniques have been used to treat retention cysts, micro-marsupialization is a relatively new, less invasive treatment modality. We describe this new method, which is not popular in Japan, and report the clinical outcomes of 13 cases of mucoceles and ranulas treated with this technique.We evaluated the therapeutic value of micro-marsupialization on the basis of cure rate and events such as infection and recurrence. As a result, ten cases (76.9%) showed complete remission of the lesions and three cases including one case of infection required retreatment.Micro-marsupialization seems to be a simple, minimally invasive and effective modality, and is well tolerated by patients. We accordingly suggest that it could be a primary treatment of choice for mucous retention cysts.
著者
山本 大介 目瀬 浩
出版者
公益社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.64, no.5, pp.274-278, 2018-05-20 (Released:2018-07-20)
参考文献数
18

Case reports describing mandibular fractures associated with external auditory canal fractures without condylar fractures are extremely rare. We report a case of mandibular and external auditory canal (EAC) fractures. A 56-year old man was referred to our department because of pain on opening and closing of the jaw. He had hypertension, diabetes mellitus, sleep apnea syndrome, and familial myoclonus epilepsy. In January 2014, he bruised his chin and precordial region when he fell down because of orthostatic hypotension. He was transported to a nearby general hospital and underwent treatment for a laceration on the chin. He was introduced to our department to receive treatment for hemorrhage from both the EAC fracture and mandibular fracture. Local examination showed disturbed mouth opening due to jaw pain and bloody discharge from both auditory canals. There was also a laceration on the chin. Computed tomography (CT) disclosed a fracture line at the mandibular symphysis and both EACs, but the auditory ossicles were not separated. The patient was treated by packing both auditory canals in consultation with the Department of Otolaryngology. We performed open reduction and internal fixation (ORIF) surgery with the patient under general anesthesia, and intermaxillary fixation (IMF) was secured for 1 week. The patient was followed up for 1 year, and healing was satisfactory with no subsequent stenosis of the auditory canal.
著者
新田 哲也 坂元 亮一 平原 成浩 松村 吉晃 中村 康大 後藤 雄一
出版者
公益社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.65, no.9, pp.599-604, 2019-09-20 (Released:2019-11-20)
参考文献数
27
被引用文献数
1 1

The side effects of peroral bisphosphonate may cause mucous membrane disorders and oral exulceration if individuals dissolve the drug inside the oral cavity on oral administration. We experienced two cases in which we strongly suspected mucous ulcurs due to this drug. Finally, the oral exulceration disappeared after providing instructions on correct administration. An 83-year-old woman was referred because of exulceration of the right mandible. She suffered from osteoporosis, thoracic vertebra compression fracture, and dementia, while taking alendronate weekly. The exulceration appeared from the right lower lip to the right mandibular molar gingiva when we absorbed pooled saliva in the right oral cavity when the patient was lying down. We instructed the patient to confirm that the tablet was completely swallowed. The ulcers in the oral cavity completely disappeared 17 days after presentation. A 74-year-old woman with osteoporosis presented because of bleeding and pain in the gingiva of the right mandible. She was taking monthly minodronate while wearing incompatible dentures. Exulceration occurred with peripheral redness ranging from the right buccal mucosa to the right molar gingiva of the mandible and the tongue/floor of her mouth, along with a ventrolateral tongue. We taught her how to swallow minodoronate correctly without dentures, and the ulcers healed 4 weeks later.
著者
宗圓 聰
出版者
公益社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.66, no.2, pp.40-51, 2020-02-20 (Released:2020-04-20)
参考文献数
24

Antiresorptive drugs, such as the bisphosphonates and the RANKL inhibitor denosumab, are currently the most widely used osteoporosis medications. These drugs increase bone mineral density (BMD) and reduce the risk of vertebral, nonvertebral and hip fractures in postmenopausal women with osteoporosis. Recently, anabolic therapy with teriparatide was demonstrated to be superior to the bisphosphonate risedronate in postmenopausal women with vertebral fracture. Treatment with the sclerostin antibody romosozumab increase BMD more profoundly and rapidly than alendronate and is also superior to alendronate in reducing the risk of vertebral and nonvertebral fracture in postmenopausal women with osteoporosis. For patients with severe osteoporosis and high fracture risk, bisphosphonates alone are unlikely to be able to provide long-term protection against fracture and restore BMD. For those patients, sequential treatment, starting with anabolic drug, followed by an antiresorptive, will likely provide better long-term fracture prevention and should be the golden standard of future osteoporosis treatment. The concept of a “drug holiday” applies only to patients taking bisphosphonates because of a transient residual antiresorptive effect after discontinuation due to skeletal retention of drug. For non-bisphosphonates, a drug holiday is not appropriate because BMD declines rapidly after treatment is stopped.
著者
今里 聡
出版者
公益社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.61, no.7, pp.360-362, 2015-07-20 (Released:2015-11-09)
参考文献数
12

Recently, Mineral Trioxide Aggregate (MTA) categorized as calcium silicate cements has been frequently used for root-end filling. MTA is advantageous in sealing of root and hard-tissue formation, and many clinical studies which reported successful results for apicoectomy using MTA are available. 4-META/MMA adhesive resins, which show superior bonding ability to dentin, are also promising materials for root-end filling. However, in addition to durable sealing, abilities to control infection or promote tissue regeneration are important for ideal root filling materials. Therefore, development of new technologies to achieve adhesive resins for root-end filling with antibacterial effects or FGF-2-releasing property is in progress.
著者
岩井 恵理華 山本 泰 飯塚 普子 末光 正昌 久山 佳代 小宮 正道
出版者
公益社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.67, no.11, pp.630-633, 2021-11-20 (Released:2022-01-20)
参考文献数
12

Dipeptidyl peptidase-4 (hereinafter referred to as DPP-4) inhibitors are used in diabetes therapy. They lower blood glucose by inhibiting DPP-4 and promoting insulin secretion. Here, we report a case of oral mucous membrane pemphigoid caused by the oral administration of a DPP-4 inhibitor. A 61-year-old female with gingival erosion and bleeding in the maxilla from the right first premolar to the left first premolar was referred to our department. On the first visit, redness, blisters, erosion, and the Nikolsky phenomenon were observed in the aforementioned region. A biopsy was performed for suspected pemphigoid. A histopathologicaldiagnosis of pemphigoid was obtained using HE staining and the fluorescent antibody method. The patient had diabetes and had been taking a combination drug containing vildagliptin (DPP-4 inhibitor) and metformin hydrochloride for two years and six months. We suspected that the pemphigoid was caused by the DPP-4 inhibitor. A request for a prescription modification was made to the internal medicine department, and the DPP-4 inhibitor was replaced with canagliflozin hydrate. The symptoms (redness, blisters, erosion, and the Nikolsky phenomenon) disappeared one month after suspension of the drug containing the DPP-4 inhibitor. Furthermore, relapse has not occurred in the 2 years since.
著者
美島 健二
出版者
公益社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.62, no.12, pp.592-601, 2016-12-20 (Released:2017-02-20)
参考文献数
35

The most common cancers in oral cavity are squamous cell carcinoma (OSSC), which accounts for more than 90% in oral cancers. The 5-year overall survival rate of early stage of OSCC is over 90%, while that of advanced stages is still poor. It is important to treat precancerous lesions including leukoplakia and erythroplakia to improve the prognosis. Malignant transformation rates of leukoplakia and erythroplakia range from 5% to 10% and 40% to 50%, respectively. Biopsy is performed to microscopically divide these lesions into oral intraepithelial neoplasia (OIN) /CIS and oral epithelial dysplasia. In addition to histological findings, immunohistochemical analysis such as Ki-67, p53, cytokeratin13, 17, and p16, is also helpful for the diagnosis. After surgical treatment, the resected specimens from OSCC patients are examined in details regarding prognostic factors, which are disease staging, resection margin free of diseases, tumor thickness, and extracapsular dissemination of lymph nodes. Furthermore, it is reported that EGFR-, NOTCH-, PI3K-, PTEN-and AKT-mediated pathways are involved in OSCC proliferation, suggesting that these factors can be expected to be promising molecular targets for OSCC treatment.
著者
森本 真弘 浅香 卓哉 鎌口 真由美 山下 映美 坂田 健一郎 大内 学 大賀 則孝 佐藤 淳 佐藤 千晴 北川 善政
出版者
公益社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.65, no.7, pp.447-454, 2019-07-20 (Released:2019-09-20)
参考文献数
22
被引用文献数
2

Palmoplantar pustulosis (PPP) is a refractory skin disorder exhibiting numerous sterile pustules on the palms and soles of the patients. PPP is related to dental focal infection and metal allergy, and the experts in dermatology and dentistry have worked together to arrive at a consensus regarding the diagnosis and treatment of PPP. However, the obvious cause of PPP remains unknown, and a standard treatment has yet to be established. In this study, we aimed to clarify the relation of PPP to dental focal infection and dental metal allergy. We evaluated 29 patients with PPP who underwent oral examination and patch testing in the Department of Oral Medicine at Hokkaido University Hospital from July 2010 through May 2014. In total, 22 of the 29 patients had positive patch test results, and flare-up was observed in one patient. Metallic component analysis revealed that the oral cavity was metal-positive in 14 of 22 patch test-positive patients. In contrast, odontogenic foci were found in 25 of 29 patients. Among 14 patients who had positive patch-test results for metal in the oral cavity, the course after metal removal could be confirmed in nine patients, and skin symptoms improved in all patients. Among 15 patients who did not have patch-test results for metal in the oral cavity, the course after treatment of odontogenic foci could be confirmed in eight patients, and symptoms improved in only one patient. This study resulted in a higher rate of improvement after removal of dental metals versus treatment of odontogenic foci, suggesting that PPP strongly correlates with dental metal allergy. However, because odontogenic foci may be treated concurrently with metal removal, an association between PPP and dental focal infection cannot be denied. In addition to the time and cost burden of metal removal, symptoms may improve naturally in some cases. Therefore, we suggest that it is necessary to consider the suitability of metal removal on a case-by-case basis.
著者
藤城 建樹 荘司 洋文 北詰 栄里 岡村 尚 吉田 和正 辺見 卓男
出版者
公益社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.64, no.8, pp.486-491, 2018-08-20 (Released:2018-10-22)
参考文献数
15

If the inferior alveolar nerve is resected by surgery for a mandibular tumor, the perception of its dominant area will be permanently lost. When we perform nerve reconstruction, autologous nerve grafting is usually performed, but there is a fault that we produce new neuropathy in the nerve-donor site. The nerve conduit, which is an artificial material, begins to be used for nerve amputation and deficiency, but there is no report about mandibular tumors. The patient was a 20-year-old man with mandibular ameloblastoma. We performed hemimandibulectomy, mandibular reconstruction with a free iliac bone graft, and inferior alveolar nerve reconstruction with a nerve conduit. The postoperative course was uneventful. Neurosensory disturbance of the mental nerve improved 5 months after surgery, and approximately normally status was recovered after 10 months. Currently, 2 years have passed since the operation, and there are no obvious abnormalities.
著者
山隈 優 廣田 誠 小栗 千里 南山 周平 光永 幸代 光藤 健司
出版者
公益社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.66, no.12, pp.610-615, 2020-12-20 (Released:2021-02-22)
参考文献数
30
被引用文献数
1 1

Delanian et al. reported the efficacy of pentoxifylline-tocopherol-clodronate (PENTOCLO) treatment for osteoradionecrosis (ORN) of the mandible in 2011. Spontaneous sequestration and epithelialization of the mandibular lesion are induced by this method. We report a case of osteoradionecrosis of the mandible which responded to treatment with PENTOCLO. A 60-year-old man was referred to our department with persistent mandibular ORN after definitive chemoradiotherapy for oropharyngeal carcinoma (T2N0M0). Periodontitis of the right second molar caused ORN, followed by pathological fracture. PENTOCLO treatment was started following 4-week antibiotic therapy. The sequestrum spontaneously separated with mucosal epithelialization two months after the treatment started. The second molar was removed at 11 months because of its increasing mobility. The extraction socket had epithelized and computed tomography (CT) showed that the pathological fracture had healed. No adverse events occurred during this treatment course. PENTOCLO may be an organpreserving treatment option for ORN of the mandible.
著者
山下 佳雄
出版者
公益社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.64, no.2, pp.39-47, 2018-02-20 (Released:2018-04-20)
参考文献数
50

The maxilla has an anatomically complex structure, and therefore recovery of morphology and function is not easily achieved in patients who have lost maxillary bone and surrounding soft tissue due to maxillary cancer. Prosthetic approaches have traditionally been used to treat these defect sites by using jaw dentures to achieve functional recovery. Jaw dentures are a useful means of enhancing intraoral stability by maintaining residual teeth and obturator appliances and of quickly improving chewing, swallowing, and speech functions. Meanwhile, recent advancements in reconstructive surgery have led to the active implementation of closure of defect sites by means of various skin flaps and bony reconstruction of the maxilla using grafts such as vascularized iliac flaps or vascularized fibular flaps. Various debates are ongoing over which criteria should be used to select the maxillary prosthetic treatment and reconstructive surgical method for maxillary defects after tumor resection. Due to their respective advantages and disadvantages, the treatment method should be chosen with consideration for the patient’s general condition and the state of the defects. Depending on the patient, a combination of both prosthetic treatment and reconstructive surgery may be necessary; the advantages of both treatments should be exploited as much as possible. Dental implants have been used in recent years to improve the therapeutic effects of both of these treatments with good outcomes.