著者
黒澤 佳弘 加藤 且也 斎藤 隆雄 横川 善之 マイケル ムツアロ 亀山 哲也
出版者
公益社団法人 日本セラミックス協会
雑誌
日本セラミックス協会 年会・秋季シンポジウム 講演予稿集
巻号頁・発行日
vol.2006, pp.367, 2006

生体親和性に優れ、タンパク質などに対して特異的な吸着を示すアパタイトは,骨充填材のみならず,タンパク質などの生体高分子の除放担体としても検討されている.しかし,一般的なアパタイトはその高い結晶性のために溶解性が低く,除放後に生体内に残存する可能性もある.そこで,生体内で溶解されやすい低結晶性のアパタイトが除放担体として注目されている.今回は,数種類の方法によって合成された非晶質リン酸カルシウム(ACP)ナノ粒子のタンパク質吸着と脱着について検討した.また, ACPナノ粒子が細胞増殖に及ぼす影響,そして細胞に対する毒性に関しても検討を行った.
著者
中根 久志 青木 早苗 野浪 亨 田中 一彦 森 勝伸 幸本 和人 刀根 如人 亀山 哲也
出版者
日本セラミックス協会
雑誌
Journal of the Ceramic Society of Japan (日本セラミックス協会学術論文誌) (ISSN:09145400)
巻号頁・発行日
vol.115, no.1338, pp.151-155, 2007
被引用文献数
2

An acid resistant fluoroapatite coated titanium dioxide (FAp-TiO_2) was synthesized by adding a fluoride ion (F^-) to hydroxyapatite (HAp), in order to avoid dissolution of the HAp at an acidic atmosphere. In this study, the optimization of synthetic conditions of FAp-TiO_2 was investigated in terms of the amount of the fluorine (F^-) added to the simulated body fluid, the reaction temperature and the time. The addition of F^- to simulated body fluid was performed after coating HAp on the surface of TiO_2 surface. The crystallinity of FAp phase generated on the TiO_2 was strongly affected by changing the reaction conditions. The optimized synthetic conditions of FAp-TiO_2 as photocatalyst were the addition of 0.25mM-0.5mM F^- in the fluid and then the reaction time for 3h at 60℃. The adsorptivity and the photocatalytic activity of the FAp-TiO_2 in the optimum conditions were investigated using the butyric acid and trimethylamine as model solutions. Consequently, the FAp-TiO_2 could obtain higher adsorptivity and photocatalytic activity for trimethylamine, rather than the uncoated TiO_2.
著者
中根 久志 青木 早苗 野浪 亨 田中 一彦 森 勝伸 刀根 如人 亀山 哲也
出版者
公益社団法人日本セラミックス協会
雑誌
日本セラミックス協会学術論文誌 : Nippon Seramikkusu Kyokai gakujutsu ronbunshi (ISSN:18821022)
巻号頁・発行日
vol.114, no.1334, pp.838-843, 2006-10-01
被引用文献数
5 11

An acid resistant fluoroapatite (FAp) coated titanium dioxide (TiO_2) was synthesized by adding a fluoride ion (F^-) to hydroxyapatite (HAp), in order to avoid dissolution of the HAp at an acidic atmosphere. In this study, different methods of adding F^- to the apatite in a simulated body fluid were tested; one was synthesized by coating a simulated body fluid including Ca^<2+>, PO_4^<3-> and F^- to the TiO_2 (method 1), and another method was by mixing the F^- after coating a simulated body fluid without the F^- to the TiO_2 (method 2). The apatite crystalline phase of the coated TiO_2 was found to increase with F^-, by using a XRD and a FT-IR. The size of crystalline apatite was strongly affected by the method of adding F^-. The size of the crystalline synthesized by method 1 was larger than that by method 2. The photocatalytic activities of the apatite coated photocatalysts to organic substrates such as propionic acid were evaluated using an ion chromatography. The deterioration of FAp coating during photooxidation of the propionic acid with an UV-irradiation was largely suppressed compared with that of the HAp coating.