著者

土井 信幸 毎田 千恵子 高橋 恵美利 井出 美晴 宮本 悦子 秋山 滋男

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.44, no.7, pp.380-392, 2018-07-10 (Released:2019-07-10)

参考文献数

22

被引用文献数

3

---

The characteristics of eye drop (ophthalmic solution) containers are reported to be associated with the appropriate use of eye drops. Since patients complain that AZORGA® Combination Ophthalmic Suspension (AZORGA® hereafter) requires more push-out force than other eye drops, there is a possibility that the container of AZORGA® is less usable than other commercially available eye drop containers in Japan. Therefore, we compared the Alconpharma container used for AZORGA® and 3 representative containers as controls, which are available in large quantities in Japan. In addition, a subjective usability questionnaire was performed in healthy adults, and the influences of containers on the subjective usability of high-viscosity eye drop suspensions, such as AZORGA®, were evaluated.The Alconpharma container showed a significantly higher squeeze force necessary to push out 1 drop of AZORGA® and a slightly higher variability in the squeeze force among instillations than that in the other 3 containers. In association with these characteristics of the containers, the subjective usability scores for “container's hardness during instillation” and “easiness of pushing 1 drop out” were significantly lower for the Alconpharma container than for the other 3 containers. These results suggest that not only the characteristics of the AZORGA® solution (high viscosity and suspension) but also those of its container affect the subjective usability of eye drop products.