著者

土井 信幸 毎田 千恵子 高橋 恵美利 井出 美晴 宮本 悦子 秋山 滋男

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.44, no.7, pp.380-392, 2018-07-10 (Released:2019-07-10)

参考文献数

22

被引用文献数

3

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The characteristics of eye drop (ophthalmic solution) containers are reported to be associated with the appropriate use of eye drops. Since patients complain that AZORGA® Combination Ophthalmic Suspension (AZORGA® hereafter) requires more push-out force than other eye drops, there is a possibility that the container of AZORGA® is less usable than other commercially available eye drop containers in Japan. Therefore, we compared the Alconpharma container used for AZORGA® and 3 representative containers as controls, which are available in large quantities in Japan. In addition, a subjective usability questionnaire was performed in healthy adults, and the influences of containers on the subjective usability of high-viscosity eye drop suspensions, such as AZORGA®, were evaluated.The Alconpharma container showed a significantly higher squeeze force necessary to push out 1 drop of AZORGA® and a slightly higher variability in the squeeze force among instillations than that in the other 3 containers. In association with these characteristics of the containers, the subjective usability scores for “container's hardness during instillation” and “easiness of pushing 1 drop out” were significantly lower for the Alconpharma container than for the other 3 containers. These results suggest that not only the characteristics of the AZORGA® solution (high viscosity and suspension) but also those of its container affect the subjective usability of eye drop products.

著者

土井 信幸 秋山 滋男 矢野 健太郎 高橋 恵美利 小見 暁子 井戸田 陽子 荻原 琢男

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.42, no.9, pp.651-658, 2016-09-10 (Released:2017-09-10)

参考文献数

17

被引用文献数

2

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Many generic products of latanoprost ophthalmic solution are commercially available. For pharmacists' guidance, patients often ask questions, such as the total number of drops to be used per bottle. However, materials, including package inserts, that can be obtained from pharmaceutical companies do not provide such information, such as the total number of drops, the volume of a drop, or sense of use regarding each preparation. In this study, we compared the total number of drops, the weight of a drop, squeezing force, and sense of use using brand-name and generic products of latanoprost ophthalmic solution to establish selection criteria.The weight of a drop exceeded 25 mg in all products, but there were significant differences among the products. In generic products, the total number of drops per bottle was lower than in the brand-name product (112.6 ± 0.9 drops), showing significant differences (10 to 20 drops). The squeezing force required for dripping differed among the products (1.5 to 5-fold). The sense-of-use score regarding the rigidity of an eye drop container reduced with the increase in the squeezing force, showing a negative correlation. The utilization of this information may improve glaucoma patients' adherence and/or reduce costs, providing beneficial information for adopting pharmaceutical preparations in medical institutions.