著者

三橋 博 金子 光 佐々木 希吉

出版者

公益社団法人 日本薬学会

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.10, no.11, pp.1119-1122, 1962

被引用文献数

1

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It was shown that DL-phenylalanine [2-<SUP>14</SUP>C] was incorporated into C-3 of two kinds of isoflavone, formononetin and genistein, by <I>Trifolium pratense</I> sp., <I>in vivo</I>.<BR>These results indicate that the aryl group undergoes a migration within the C<SUB>6</SUB>-C-C-C fragment, and this observation agrees with Grisebach's experimental data.

著者

本間 秀彰 橋本 義人 宮崎 信義 松本 隆亜 佐々木 希吉

出版者

日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.33, no.5, pp.457-462, 2007-05-10

参考文献数

24

被引用文献数

3 5

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To ascertain the use of health foods by patients and the associated problems, we asked 364 patients who brought prescriptions to our pharmacy to fill out a questionnaire. The questions asked aimed to determine the percentage of patients using health foods, the purpose of using them and the kinds of health foods used as well as the period, the frequency, amounts, and the effects of using them. Other questions concerned the person advising them on the use of health foods, the side effects of health foods, and the awareness of patients regarding the interactions between drugs and health foods. The knowledge obtained from the responses received should enable us to provide better pharmaceutical care to patients.

著者

川松 豊 杉原 弘貞 佐々木 希吉 森本 浩

出版者

天然有機化合物討論会

雑誌

天然有機化合物討論会講演要旨集

巻号頁・発行日

no.13, pp.99-106, 1969-09-01

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I. Synthesis of 2,3-dialkoxy-5-alkyl-1,4-benzoquinone a) 4a and 4b obtained from 1 were oxidized with organic peracids to give 2,3-dimethoxy-(5a) and 2,3-diethoxy-5-methyl-1,4-benzoquinone (5b). b) 9a and 9b obtained from 6 were oxidized in a similar manner to give 5a and 10. II. Synthesis of isoprenoid quinones The authors found two new condensation methods. a) Method using an N-sulfinylamine. A solution of hydroquinone (12), methyl N-sulfinylanthranilate (14) and phytol (13) in dioxane was heated and oxidized with ferric chloride to give 2,3-dimethoxy-5-methyl-6-phytyl-1,4-benzoquinone (15) as well as by-products 16 and 17. The structures of 16 and 17 were made clear and the reaction mechanism was discussed. The results are shown in Table 1. b) Method using a metal. A solution of 5a and X-CH_2-CH=C-CH_3-CH_2-R in petroleum ether was treated with slightly an excess amount of amalgamated zinc at the room temperature to give 18. The product 18 was obtained also from hydroquinone (12). The reaction mechanism and the results are shown in Table 2. III. Stereochemistry of isoprenoid quinones It has been so far known that the steric configuration of the side chain of naturally occurring isoprenoid quinones is all-trans, but synthesized isoprenoid quinones inevitably contain a small amount of the cis-isomer. Then, the authors separated these isomers by the column chromatography to confirm their yields and to compare their NMR spectra with each other. The relationship between the structures of the quinones and the biological activity is also mentioned.

著者

川松 豊 杉原 弘貞 佐々木 希吉 森本 浩

出版者

天然有機化合物討論会実行委員会

雑誌

天然有機化合物討論会講演要旨集

巻号頁・発行日

vol.13, pp.99-106, 1969

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I. Synthesis of 2,3-dialkoxy-5-alkyl-1,4-benzoquinone a) 4a and 4b obtained from 1 were oxidized with organic peracids to give 2,3-dimethoxy-(5a) and 2,3-diethoxy-5-methyl-1,4-benzoquinone (5b). b) 9a and 9b obtained from 6 were oxidized in a similar manner to give 5a and 10. II. Synthesis of isoprenoid quinones The authors found two new condensation methods. a) Method using an N-sulfinylamine. A solution of hydroquinone (12), methyl N-sulfinylanthranilate (14) and phytol (13) in dioxane was heated and oxidized with ferric chloride to give 2,3-dimethoxy-5-methyl-6-phytyl-1,4-benzoquinone (15) as well as by-products 16 and 17. The structures of 16 and 17 were made clear and the reaction mechanism was discussed. The results are shown in Table 1. b) Method using a metal. A solution of 5a and X-CH_2-CH=C-CH_3-CH_2-R in petroleum ether was treated with slightly an excess amount of amalgamated zinc at the room temperature to give 18. The product 18 was obtained also from hydroquinone (12). The reaction mechanism and the results are shown in Table 2. III. Stereochemistry of isoprenoid quinones It has been so far known that the steric configuration of the side chain of naturally occurring isoprenoid quinones is all-trans, but synthesized isoprenoid quinones inevitably contain a small amount of the cis-isomer. Then, the authors separated these isomers by the column chromatography to confirm their yields and to compare their NMR spectra with each other. The relationship between the structures of the quinones and the biological activity is also mentioned.

著者

三橋 博 金子 光 佐々木 希吉

出版者

公益社団法人日本薬学会

雑誌

Chemical & pharmaceutical bulletin (ISSN:00092363)

巻号頁・発行日

vol.10, no.11, pp.1119-1122, 1962-11-25

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It was shown that DL-phenylalanine [2-^<14>C] was incorporated into C-3 of two kinds of isoflavone, formononetin and genistein, by Trifolium pratense sp., in vivo. These results indicate that the aryl group undergoes a migration within the C_6-C-C-C fragment, and this observation agrees with Grisebach's experimental data.

著者

三橋 博 佐々木 希吉 清水 譲

出版者

公益社団法人日本薬学会

雑誌

Chemical & pharmaceutical bulletin (ISSN:00092363)

巻号頁・発行日

vol.11, no.11, pp.1452-1455, 1963-11-25

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The whole plant of Perugularia extensa N. E. Br. was proved to contain a glycoside mixture which showed strong Keller-Kiliani reaction, suggesting the presence of a 2-deoxy-sugars in the sugar part. The sugar fraction obtained by acid hydrolysis was found to contain D-cymarose, D-sarmentose, L-oleandrose, and D-glucose by a paper chromatographic comparison with authentic specimens. Uzarigenin and a new glycoside (m.p. 244〜248°) were found.