著者
高谷 芳明 内沢 秀光 松江 一 奥崎 文一 鳴海 文昭 佐々木 甚一 石田 邦夫
出版者
The Pharmaceutical Society of Japan
雑誌
Biological and Pharmaceutical Bulletin (ISSN:09186158)
巻号頁・発行日
vol.17, no.6, pp.846-849, 1994-06-15 (Released:2008-04-10)
参考文献数
13
被引用文献数
20 26

Squid ink, which has little commercial use and is usually discarded, was extracted using a Tris-HCl buffer (pH 6.8). The extract was fractionated using DEAE Sephacel ion-exchange chromatography and Sephacryl S-300 gel filtration to give a peptidoglycan fraction which exhibited strong antitumor activity against Meth-A fibrosarcoma in BALB/c mice following intraperitoneal administration. The fraction was composed of 7.8% peptide, 57% polysaccharide and 30% pigment. The polysaccharide component had a unique structure with equimolar ratios of GlcA, GalNAc and Fuc. Since the fraction has no direct cytotoxic effect on Meth-A cells, inhibition of tumor growth may be due to stimulation of host-mediated responses.
著者
佐々木 甚一
出版者
弘前大学
雑誌
弘前大学医学部保健学科紀要 (ISSN:13471112)
巻号頁・発行日
vol.5, pp.145-156, 2006
被引用文献数
1