1 0 0 0 OA 血管の新生と再生におけるVEGFの役割
- 著者
- 佐藤 靖史 安部 まゆみ
- 出版者
- 一般社団法人 日本炎症・再生医学会
- 雑誌
- 炎症・再生 (ISSN:13468022)
- 巻号頁・発行日
- vol.22, no.3, pp.169-177, 2002-05-30 (Released:2010-04-12)
- 参考文献数
- 54
- 被引用文献数
- 1
Angiogenesis plays an essential role in a wide range of physiologic and pathologic states. Numerous factors are reported to be involved in angiogenesis. Among them, vascular endothelial growth factor (VEGF), a homodimer-secreted protein, is one of the most important factors. VEGF was initially termed vascular permeability factor (VPF) and was shown to induce vascular permeability, as well as to promote angiogenesis. There are three tyrosine kinase-type VEGF receptors, Fit-1 (VEGFR-1), KDR/Flk-1 (VEGFR-2), and Flt -4 (VEGFR-3) . Flt -1 and KDR/Flk-1 are expressed in vascular endothelial cells (ECs), whereas Flt -4 is preferentially expressed in lymphatic ECs. VEGF binds to Flt -1 and KDR/Flk-1, and to a membrane protein neuropilin-1 on ECs. Neuropilin-1 does not contain a tyrosine kinase domain, but is functionally associated with VEGF receptors. The VEGF-KDR/Flk-1 mediated signal is indispensable for the differentiation of ECs and blood cells in embryo. The VEGF-KDR/Flk-1 mediated signal also play an important role in adult, and stimulates protease synthesis in ECs and promotes EC migration and proliferation. VEGF-induced angiogenesis results beneficial effects in several animal models of myocardial or limb ischemia. Currently, several clinical trials are ongoing to test the hypothesis that VEGF-induced angiogenesis may be beneficial for these conditions.
1 0 0 0 OA 慢性腎臓病における内因性バゾヒビンファミリーの腎保護効果と臨床的意義に関する検討
慢性腎臓病(CKD)は末期腎不全・心血管疾患の危険因子である。本研究では、内在性血管新生制御因子Vasohibin-1のCKDの病態における機能的解析を行った。Vasohibin-1欠損マウスにおいて野生型マウスに比して、糖尿病性腎症、尿細管間質病変、急性腎障害が増悪した。CKD患者にて、腎組織でのVasohibin-1発現は半月体形成、間質炎症細胞浸潤と相関し、血・尿中Vasohibin-1濃度高値群では、将来的な腎機能低下進展のリスクが増加した。内因性Vasohibin-1のCKD病態における腎保護的効果並びに新規バイオマーカーとしての可能性が示唆された。