著者

田中 邦雄 佐野 文男 阿部 善右衛門

出版者

一般社団法人 日本生体医工学会

雑誌

医用電子と生体工学 (ISSN:00213292)

巻号頁・発行日

vol.12, no.2, pp.81-89, 1974-04-30 (Released:2011-03-09)

参考文献数

25

被引用文献数

1

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Several papers on the applications of the nuclear magnetic resonance (NMR) technique-for the biological measurements have been published since the first proposal of the NMR blood flowmeter by Bowman. However, the problems arising inherently from the non-invasive measurements of the specified area in the body were not discussed in these papers. The authors proposed previously the magnetic focusing technique as one of the new approaches and discussed some problems related to this technique.In this paper, some basic problems of the applications of NMR for the non-invasive measurements are discussed and the fundamental properties affecting the measuring sensitivity attained by the magnetic focusing technique is analyzed. The problems treated and the obtained results are as follows : 1) The relations among parameters such as relaxation times and radio frequency magnetic field which influence the measuring sensitivity are experimentally analyzed.2) The distributions of RF magnetic field inside or outside the transmitter coil are theoretically calculated. Approximate values of relaxation time of 1-2 sec. and 0.1-1 sec. are experimentally obtained respectively with the various body fluids and tissues of the dog and the human. Philosophy of choosing the appropriate parameters are discussed based on these results by taking the saturation factor in Bloch's equation and the measuring sensitivity into account.3) Application for the tumor detection is discussed and the differences of 20% and 200% in relaxation time between normal and cancer cases are experimentally obtained respectively with the tissues from the stomach and the breast. Further, it has been found that the relation between hematocrit of blood and its relaxation time was linear.4) The deterioration of signal output by body tissues is examined by a model experiment. According to this experiment, it is shown that the deterioration of S/N ratio was equal to approximately 30%, at f = 60 MHz.5) From above results, in the case of applying our proposed magnetic focusing technique, the resolution or the minimally detectable volume of water in the typical organs by S/N of unity at resonance frequency of 60 MHz should be about 0.3 ml.

著者

西田 修 佐野 文男 佐藤 直樹 五十嵐 究 木村 純 葛西 洋一

出版者

一般社団法人 日本消化器外科学会

雑誌

日本消化器外科学会雑誌 (ISSN:03869768)

巻号頁・発行日

vol.17, no.9, pp.1758-1762, 1984 (Released:2011-03-02)

参考文献数

17

被引用文献数

2 3

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1968年から1982年までに当科で経験した40歳未満の若年者大腸癌23例の病態および治療成績に検討を加えた. 若年者大腸癌は全大腸癌の9.7%で, 平均病悩期間は4.5ヵ月, 腫瘍長径は6.6cmと高年者より発育が速い. 組織学的には低分化腺癌 (17%) と粘液癌 (33%) の頻度が高い. n (+) は若年者49%, 高年者38%, V (+) は若年者48%, 高年者32%, ly (+) は若年者47%, 高年者37%と, いずれも若年者の頻度が高い. 臨床症状は若年者に腹痛および肛門痛が39%と多い. 若年者大腸癌の再発率は60%, 5生率44%とその成績は不良で, 特に, 肝転移再発が38.5%と高いため, 門脈内への化学療法が望まれる.

著者

田中 邦雄 清水 哲也 佐野 文男 阿部 善右衛門

出版者

一般社団法人 日本生体医工学会

雑誌

医用電子と生体工学 (ISSN:00213292)

巻号頁・発行日

vol.14, no.1, pp.25-32, 1976-02-29 (Released:2011-03-09)

参考文献数

19

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Since R. Damadian suggested the detectability of tumors by nuclear magnetic resonance (NMR), the authors have focused their attention on the facts such as the quantities related to the kinds of water and tissues. And at least qualitative information could be non-invasively obtained.In this paper, in order to clarify the applicabilities of our proposed magnetic focusing method for non-invasive tumor detection, the nuclear magnetic relaxation time (T1) of transplanted malignant tumor (AH-66) in rat, excised normal and cancerous tissues in man were measured in vitro experiment.The resultant findings are summarized as followings.1) Transplanted malignant tumor in rat showed (30-120) % longer value of T1 than that of the respective normal tissues.2) In 14 cases of the uterus, breast and stomach in man, the T1 of cancerous tissues increased (10-150) % than that of their normal portions.3) When mixed tissue was studied, T1 changed as the ratio of tumor to normal tissue changed.4) The longer the time elapsed, the greater the T1 value exhibited by normal and the smaller the T1 measured for cancerous tissue. When both normal and cancerous tissues coexist, T1 decrement of the tissue is small.