著者

小野 昇 加治 有恒

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.38, no.2, pp.115-127, 1980-02-01 (Released:2009-11-13)

参考文献数

110

被引用文献数

21 24

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Recent advances of the chemistry of aliphatic nitro compounds are reviewed, in which the following items are covered. 1) Preparation of aliphatic nitro compounds. 2) Reaction of aliphatic nitro compounds which includes substitution and elimination reaction of the nitro group, conversion of the nitro group to the carbonyl or amino group and organic synthesis using nitroolefins.

著者

野口 照久 橋本 喜信 小坂 璋吾 菊池 正義 宮崎 幸信 先本 礼次 加治 有恒

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.88, no.3, pp.344-352, 1968-03-25 (Released:2008-05-30)

参考文献数

21

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Some observations were made on the anti-trichophyton action of 2-naphthyl N-methyl-N-arylthiocarbamate (A). In vitro antifungal activity decreased slightly when the thiocarbamate was changed to carbamate, and a marked lowering in the in vitro effect was observed. The antifungal activity disappeared entirely when the thiocarbamate was changed to dithiocarbamate and thiolcarbamate. When the aryl group in A is a naphthyl, antifungal activity is present only when 1-naphthyl is present and other three combinations are entirely ineffective. When the aryl is a substituted phenyl, compounds having methyl, methoxyl, or halogens, those with the Hammet constant in the range of +0.23 to -0.27, have marked antitrichophyton activity in vivo, but those with nitro, formyl, carboxyl, sulfonamido hydroxyl, or dimethylamino group show marked decrease in the effect. The series of compounds having the A type will henceforth be designated as naphthiomates.

著者

野口 照久 小坂 璋吾 橋本 喜信 菊池 正義 宮崎 幸信 加治 有恒

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.88, no.3, pp.353-358, 1968-03-25 (Released:2008-05-30)

参考文献数

16

被引用文献数

1 2

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Examinations were made on the effect of oral administration of 2-naphthyl N-methyl-N-arylthiocarbamates (naphthiomates), an effective antimicotic agent for external use, against experimental trichophytosis. Finely powdered 2-naphthyl N-methyl-N-(m-tolyl)-thiocarbamate (naphthiomate-T) and 2-naphthyl N-methyl-N-(1-naphthyl) thiocarbamate (naphthiomate-N) showed an effect comparable to griseofulvin in about four-fold dose of the latter. In vivo metabolism of naphthiomate-T was examined in guinea pigs and rabbits, and it was found that the majority is excreted in the feces without decomposition, and little is absorbed through the intestinal tract. N-Methyl-m-toluidine and β-naphthol were detected from urine, feces, and blood as the metabolites.