著者

北口 博司

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.53, no.5, pp.381-391, 1995-05-01 (Released:2009-11-16)

参考文献数

59

被引用文献数

1

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In the past decade, in has been established that enzymes exhibit high catalytic activity as a solid state in organic solvents containing little or no water. Because organic solvents are better reaction media than water for most synthetic transformations, such has been applied to a number of organic reactions.This article is intended to provide mechanistic understanding of this phenomenon, which counters conventional wisdom. The key concept here is the high rigidity of protein's conformation under limited water content conditions : the balance of its thermodynamic stability and kinetic rigidity is essential for the enzyme's high catalytic activity and selectivities in organic media. Some applications for organic synthesis are also presented.

著者

出海 滋 上村 博 北口 博司 水船 栄作

出版者

社団法人 可視化情報学会

雑誌

可視化情報学会誌 (ISSN:09164731)

巻号頁・発行日

vol.20, no.1Supplement, pp.361-364, 2000-07-01 (Released:2009-09-03)

参考文献数

3

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A high energy industrial X-ray computed tomography system using silicon semiconductor detectors (Si-SSD) and electron linear accelerator (LINAC) was developed to obtain high resolution 3D images of high density and large scale object. To increase photon sensitivity, detector elements were placed parallel to the X-ray beams. The obtained sensitivity of 20% for X-ray of 3MeV was 3×104 times higher than that of X-ray films. It was clarified that the photon sensitivity of X-ray detectors restricts the performance of high energy X-ray CT, and it is shown that a CT image of 200mm thick iron object can be obtained with 0.2mm space resolution.