- 著者
- 工藤 玄恵 鈴木 晟幹 塚本 哲
- 雑誌
- 東京医科大学雑誌 (ISSN:00408905)
- 巻号頁・発行日
- vol.66, no.4, pp.631, 2008-10-25
1 0 0 0 陸海軍の漢文 : 最近十年
1 0 0 0 OA 高齢者におけるアミカシン硫酸塩1日1回400mg投与法の有効性と安全性の検討
- 著者
- 松木 祥彦 塚本 哲也 細山田 真 渡部 多真紀 渡辺 茂和 土屋 雅勇
- 出版者
- Japanese Society of Drug Informatics
- 雑誌
- 医薬品情報学 (ISSN:13451464)
- 巻号頁・発行日
- vol.15, no.2, pp.51-56, 2013 (Released:2013-09-05)
- 参考文献数
- 17
Objective: In previously reported comparisons of aminoglycoside antimicrobials administered once daily versus multiple administration, toxicity was found to be equal or lower while efficiency remained high. However, there are few reports on the clinical condition of targeted elderly persons. The objective of this study was to evaluate the once-daily dosing regimen of 400 mg of AMK involving elderly pneumonia patients aged 75 years or older with regard to clinical evaluation including the efficacy and toxicity.Methods: A survey to clinically evaluate the efficacy and toxicity of 400 mg AMK administered once daily for 30 min at 24 h intervals was carried out. One hundred twenty-seven patients with pneumonia and who were 75 years or older at Funabashi General Hospital were targeted, with the aim of an expected clinical effect of Cmax/MIC≥ 8-10. Serum concentration monitoring was carried out after administration began.Results: There were 121 patients (95.3%) of controlled AMK concentration with a trough serum concentration of <10 μg/mL, which is a safe concentration range. There were 6 patients (4.7%) where trough serum concentration in the toxic range >10 μg/mL, with an average at 15.1±5.0 μg/mL, and the average administration days were 7.5 ± 3.3 days. Moreover, before/after AMK administration, there were 3 patients (2.4%) where CRE values increased more than a 150% over the previous values, and were evaluated as renal dysfunction. Average trough serum concentration at that time was 3.6 ± 1.1 μg/mL, and average number of days of administration were 13 ± 1.4 days. Patients of trough serum concentration in the toxic range >10 μg/mL were not included. The average peak serum concentration calculated by Winter’s pharmacokinetic parameter and the 1-compartment model was 35.3 ± 8.0 μg/mL, and the average Cmax/MIC which correlates with the AMK effect was 9.9 ± 2.2. The treatment was effective for 83 (65.4%) of the 127 patients.Conclusion: By once-daily administration of AMK 400 mg to aged persons 75 years or older, change in trough serum concentration into a safe range and Cmax/MIC≥ 8-10, the level at which clinical effectivity can be expected, could be achieved. This administration method is shown to be useful in maintaining AMK in the target serum concentration range for aged persons.
1 0 0 0 OA 第1次自己回帰モデルによるゆらぎの解析
- 著者
- 藤田 貴行 塚本 哲 多田 茂
- 出版者
- 一般社団法人 日本機械学会
- 雑誌
- 日本機械学会論文集C編 (ISSN:18848354)
- 巻号頁・発行日
- vol.77, no.780, pp.3017-3024, 2011 (Released:2011-08-25)
- 参考文献数
- 35
- 被引用文献数
- 2
1/f noises, the power spectrum density (PSD) of signals inversely proportional to the frequency, have been observed in various types of physical and physiological systems; e.g. current and heart beat. 1/f noise is suggested to be generated by superimposing stochastic processes. Among stochastic processes, autoregressive process is suitable for analyzing physical and physiological systems in that the autoregressive process is time-discrete. A time-discrete model is suitable for analyzing those systems because those systems are observed in time-discrete manner as well. However, it is obscure whether 1/f noises are generated by superimposing those autoregressive processes. In this study, first order autoregressive (AR(1)) processes were superimposed with varied the process parameter and a driving noise. As a result, PSD of superimposed time sequences was inversely proportion to the frequency when the process parameter and a driving noise were a uniformly distribution and white noises, respectively. This result suggests that 1/f noises could be generated from the superimposing AR(1) processes when the process parameter is distributed uniformly.
1 0 0 0 OA 古事記・祝詞・風土記
1 0 0 0 IR Stage D2前立腺癌に対する内分泌化学療法 : 化学療法開始時期からみた有用性の検討
- 著者
- 塚本 哲郎 福井 巖 木原 和徳 後藤 修一 北原 聡史 小林 剛 児島 真一 大島 博幸
- 出版者
- 泌尿器科紀要刊行会
- 雑誌
- 泌尿器科紀要 (ISSN:00181994)
- 巻号頁・発行日
- vol.42, no.5, pp.351-356, 1996-05
シスプラチンを含む全身化学療法を用いて治療したステージD2前立腺癌患者29例を3群に分けた. 1)H群:ホルモン療法が化学療法より4週を越えて先行したもの(9例). 2)C群:化学療法がホルモン療法より4週を越えて先行したもの,又は化学療法単独治療例(9例). 3)HC群:ホルモン療法と化学療法の関始時期の差が4週以内のもの(11例). Kaplan-Meier法による5年生存率は,H群が18%, C群が28%, HC群が78%で,HC群が他の2群に比べ良好であったWe retrospectively analyzed 29 patients with stage D2 prostatic cancer who had been treated with chemotherapy at the urological clinic of Tokyo Medical and Dental University Hospital between 1983 and 1992 to evaluate the efficacy of chemotherapy for advanced prostatic cancer. The patients were divided into three groups according to the starting time of chemotherapy in relation to hormone therapy; 9 patients who received chemotherapy more than four weeks after the initial hormone therapy (group H), 9 patients who received chemotherapy only or in combination with the hormone therapy more than four weeks previously (group C), and 11 patients in whom both therapies were started within four weeks (group HC). Follow-up period ranged from four to 108 months averaging 35. Combination chemotherapy including cisplatin was administered one to 17 times with the median of five. The five-year survival rates estimated by Kaplan-Meier method were 18% in group H, 28% in group C, and 78% in group HC, respectively (HC vs. C: p < 0.05, HC vs. H: p = 0.059). These findings indicate that a combination chemotherapy including cisplatin may improve the prognosis of patients with advanced prostatic cancer when it is started with the initial hormone therapy simultaneously.