著者

大塚 康民 岩田 吉弘 菊川 あずさ

出版者

航空医学実験隊

雑誌

航空医学実験隊報告 (ISSN:00232858)

巻号頁・発行日

vol.47, no.3, pp.153-161, 2007-09

著者

吉田 真平 藤田 真敬 大塚 康民 柳田 保雄 柏崎 利昌 田村 敦 別宮 愼也 森本 浩吉

出版者

航空医学実験隊

雑誌

航空医学実験隊報告 (ISSN:00232858)

巻号頁・発行日

vol.58, no.3, pp.27-40, 2018 (Released:2018-11-27)

参考文献数

75

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In Japan, “hay fever”, seasonal allergic rhinitis caused by pollen, has become more popular and has been called national affliction. Although there are less serious symptoms of hay fever, symptoms including sneezing, runny nose and itchy eye, sleep impairment, fatigue, impairment of learning and cognitive performance, have potential safety risks for flying or driving. The usage of some medications such as anti-histamines with less adverse effects on central nervous system, are approved for pilots under an appropriate regulation. However, the criteria of approval and conditions in the regulations differs from organizations in countries. In this article, we summarize current medications for “hay fever” including antihistamines, montelukast, subcutaneous and sublingual immunotherapy. We also compare aeromedical regulations for these medications between Japan and U.S.. The immunotherapy, minimizing allergic reaction for “hay fever”, may be one of the potential option for pilots.

著者

大塚 康民 岩田 吉弘 菊川 あずさ 小野沢 昭彦 宮本 吉教

出版者

航空医学実験隊

雑誌

航空医学実験隊報告 (ISSN:00232858)

巻号頁・発行日

vol.47, no.3, pp.153-161, 2007

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The Blue Impulse is the aerobatic team in Japan Air Self-Defense Force. During aerobatic flight,the degree of flight stress (physical and psychological) in pilots is considered to be very high.However, there are few reports concerning endocrinological responses (catecholamine (CA) andchromogranin-A (CgA)) to aerobatic flight. Then, we determined the levels of urinary CA andsalivary CgA during actual aerobatic flight training. Urine and saliva were collected before and afterthe flight from eight healthy pilots to measure the levels of CA (noradrenaline (NA) and adrenaline(Ad)) and CgA. Although the levels of NA for postflight were unchanged for preflight, the levels ofAd for postflight were higher than for preflight. Otherwise, the levels of CgA for preflight wereremarkably higher than control level as reported in previous literatures, and the levels of CgA forpostflight were almost the same as for preflight. Our results suggest that the levels of Ad and CgAwere presumably altered by psychological stress associated with aerobatic flight training in the BlueImpulse pilots.

著者

大塚 康民 岩田 吉弘 小野沢 昭彦 宮本 吉教

出版者

航空医学実験隊

雑誌

航空医学実験隊報告 (ISSN:00232858)

巻号頁・発行日

vol.46, no.4, pp.109-113, 2006

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Urinary catecholamine responses of fighter pilots were investigated in Aerial Combat Maneuver(ACM). The levels of urinary adrenaline (Ad) and noradrenaline (NA) were determined in fighterpilots during ACM with three types of aircraft (F-4, F-15 and F-2). The levels of Ad for post-flightwere significantly higher than for pre-flight, while changes were not significant for NA. The ratios(post-/pre-flight) of Ad in ACM with different types of aircraft are relatively similar values. Ourresults indicate that the ratio of urinary Ad as a good indicator to stress adaptation during ACM infighter pilots.

著者

大塚 康民 溝端 裕亮 西 修二 小林 朝夫 菊川 あずさ

出版者

航空医学実験隊

雑誌

航空医学実験隊報告 (ISSN:00232858)

巻号頁・発行日

vol.62, no.1, pp.1-9, 2022-03-01 (Released:2022-10-30)

参考文献数

18

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Flight line personnel are exposed to exhaust emissions from aircraft engine during line maintenance work. The exhaust emissions include volatile monocarboxylic acids (VMCAs) that can cause sensory irritation of eyes, nose and throat. The purpose of our study was to determine levels of VMCAs in the exhaust emissions from F-15 fighter aircraft and T-4 JASDF jet trainer. The VMCAs in the exhaust emissions were collected by using a honeycomb diffusion denuder device, and analyzed by gas chromatography. Formic acid and acetic acid were detected in both F-15 and T-4 aircrafts. Higher levels of formic acid (163 ppb) and acetic acid (104 ppb) were detected in T-4, although those were under irritation threshold and the exposure limitations. The present results suggested that health risk of flight line personnel to those volatile acids were limited.

著者

高澤 千智 藤田 真敬 小林 朝夫 大塚 康民 鳥畑 厚志 大類 伸浩 高田 邦夫 立花 正一 柏崎 利昌 別宮 愼也

出版者

航空医学実験隊

雑誌

航空医学実験隊報告 (ISSN:00232858)

巻号頁・発行日

vol.56, no.3, pp.67-77, 2016 (Released:2020-04-11)

参考文献数

45

被引用文献数

1

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It has been issued that many accidents are caused by impaired driving or impaired flying due to side effects of medications. In 2013, US Federal Aviation Agency (FAA) warned about aircraft accidents due to side effects of medications. Japan Ministry of Internal Affairs and Communications (JMIAC) also made recommendations to Japan Ministry of Health, Labor and Welfare (JMHLW) to confirm notification about driving ban in the patient package insert. The aviators who use an impairing medication are required to wait an appropriate periods after last medications before flying. FAA defines a waiting time from last medications to flight as five times of pharmaceutical half-lives. Japan Ministry of Land, Infrastructure, Transport and Tourism (JMLIT) also defines as two times the dosing interval. The dosing interval is generally determined by pharmaceutical half-lives. Considering above situations, Japan Air Self-Defense Force, Aeromedical Laboratory (JASDF AML), recommends a waiting time from last medications to flight as five times of pharmaceutical half-lives. Newly marketed medications are monitored through post-marketing surveillance and reviewed qualification for aviators. Monitoring periods are three years or more in US Air Force, but one year in FAA, JMLIT and JASDF. We review aeromedical decision making for the safe flight with medicated aviators and related articles.